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ProteomicsPredictive modelling of brain metastasis development from cancer and non-invasive biomarker-based risk assessment leveraging DNA methylation signatures
Brain metastases (BM) are the most common and among the most deadly brain tumors. Currently, there are no reliable predictors of BM development from primary cancer, limiting early intervention. Here, we obtained 364 tumor/plasma samples from a large cohort of lung adenocarcinoma (LUAD) and BM patien...
ORGANISM(S): Homo sapiens (Human) 
2025-03-21 | PXD048525 | Pride
Brain metastases Lung adenocarcinoma Dna methylation Proteomics Biomarkers 
UnknownAlterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers.
Not available
S-EPMC6366295 | biostudies-literature
ProteomicsHuman EGFR AP-MS project
Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-23 | MSV000079525 | MassIVE
ProteomicsCancer proteome and metabolite changes linked to SHMT2
To screen for proximate and interacting proteins of SHMT2 in HeLa cells, the BioID method was employed, which consists of biotinylation of proteins in the vicinity of FlagBirAR118G –SHMT2 followed by streptavidin-based affinity capture and mass spectrometry identification. Experimental procedures we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD004629 | Pride
Streptavidin Shmt2 Ms Bioid 
ProteomicsProteomics and metabolomics reveal changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on a engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treatin...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD004954 | Pride
Metabolism Shmt2 Sodium benzoate Quantitative proteomics Interactome Lc-ms/ms 
ProteomicsMitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer
NSCLC accounts for 85% of lung cancers, the most frequently diagnosed and leading cause of cancer related death. An ACO2-iron acis regulates intracellular iron and consequently the particularly aggressive phenotype associated with NSCLC engraftment and poor prognosis. These findings suggest that NSC...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-19 | PXD028556 | Pride
Aggressiveness Engraftment Nsclc Aco2 Iron 
ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled by analysis of gene copy number variation, whole exome sequence, methylome, transcriptome, proteome, and phospho(Tyr)-proteome. Proteome profiling resolved the known major histology subtypes and r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-24 | PXD016579 | Pride
Nsclc Tmt Lung Pdx 
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080218 | MassIVE
OtherProteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.
Data from ProteomeXchange, PXD ID: PXD000788. File: T1041A_Cont3.mzml. Published as part of Mol Cell Proteomics. 2014 Jul;13(7):1644-58 . From the Abstract: {{i}} ass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and protein-protein interactions of wild ty...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310004705 | GPMDB
Resource Reanalysis 
ProteomicsData Dependent-Independent Acquisition (DDIA) Proteomics
data for DDIA (Data Dependent-Independent Acquisition) experiment
ORGANISM(S): Homo Sapiens (human) 
2020-05-04 | MSV000085371 | MassIVE
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