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ProteomicsBALF exosomes - Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules
Using 8-plex iTRAQ labelling exosmes isolated from bronchial lavage (BALF) were analyzed by LC-MS/MS. The measurements compared control subjects with sarcoidosis patients (15 in all) ; five with löfgrens syndrome and 10 with regular sacroidosis
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001808 | Pride
Sarcoidosis Exosome Balf 
ProteomicsCIP2A interactome in human Th17 Cells
CIP2A immunoprecipitation (IP) was carried out with two specific anti CIP2A antibodies that recognize distinct regions of CIP2A protein and respective Immunoglobulin G (IgG) were used in control IPs as a negative control. The digested samples were analyzed by LC-MS/MS to identify CIP2A protein netwo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD008983 | Pride
Th17 cells Cord blood Cip2a Interactome Lc-ms/ms 
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Recent data have shown that Hypermethylated in cancer 1 (HIC1) is an important contributor to iTreg cell development and function. Using affinity-purification and tandem mass spectrometry we systematically characterized the HIC-1 interactome in human iTreg cells. On the basis of these data, we have ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD039337 | Pride
Hic1  interactome  immunoprecipitation  proteomics  foxp3  protein complex  runx1  regulatory t cells  t cell differentiation  tgf-β  treg  itreg. 
ProteomicsMapping interactome networks of FOSL1 and FOSL2 in human Th17 cells
The differentiation of Th17 cells is controlled by a complex network of transcription factors (TFs), including FOS and JUN proteins of the AP-1 family. The FOS-like proteins, FOSL1 and FOSL2 have recently been reported to control Th17 responses. The molecular mechanisms dictating their roles, howeve...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD025729 | Pride
Human Th17 cells Interactomics Lc-ms/ms 
ProteomicsMinigut Cellular Proteome and Secretome
A mouse minigut Organoid model analysed using quantitative proteomics to measure proteins expressed in the crypt and villi –like cellular states, additionally providing novel details of the secreted proteins associated with these conditions.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD023737 | Pride
Lc-ms/ms Celiac disease 
ProteomicsPlasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease
Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten chal...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD069597 | Pride
Human Lc_msms Celiac disease Plasma 
ProteomicsHuman Th17 Cell differentiation
The early stages of human Th17 Cell differentiation were studied using label free proteomics to compare Th17 polarized CD4+ human T cells at 24 h and 72 h with activated cells (72 and 24 h) and Thp cells.
ORGANISM(S): Homo sapiens (Human) 
2019-01-28 | PXD008973 | Pride
Th0 Human Cord blood Th17 Lc-ms/ms 
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
PXD038532 | panorama
ProteomicsSerum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Aims/hypothesis: Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old childre...
ORGANISM(S): Homo Sapiens 
PXD033946 | panorama
UnknownHigh tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.
Not available
S-EPMC8053682 | biostudies-literature
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