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MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
ProteomicsAssessment of biarsenical dye-reactive cysteine residues of human metallothionein MT1E
Metallothioneis are low-molecular weight proteins engaged in zinc and copper ion homeostasis and redox potential regulation of the cell. Their clinical importance lies in their role in cancer resistance to cisplatin related drugs, which is related to their capability of binding sole toxic metal ions...
ORGANISM(S): Homo sapiens (Human) 
2024-12-16 | PXD048982 | Pride
Alkylation Mse protein in vitro modification analysis Biarsenical dye Human Metallothionein Crash Lc-mse 
MetabolomicsThe Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is ...

2021-12-03 | MTBLS2288 | MetaboLights
MetabolomicsField study of the fire blight resistant cisgenic apple line C44.4.146

Cisgenesis, the genetic modification of a plant with genes from a sexually compatible plant, was used to confer fire blight resistance to the cultivar 'Gala Galaxy' by amendment of the resistance gene FB_MR5, resulting in the line C44.4146. To verify whether cisgenesis changed other tree-, flower...

2022-12-19 | MTBLS5810 | MetaboLights
ProteomicsMycobacterium smegmatis cultured in different carbon sources to induce in vitro cholesterol consumption reveals alterations in immune response after infection: a macrophage proteomics analysis.
During Tuberculosis, Mycobacterium uses host macrophage cholesterol as a carbon and energy source. To mimic these conditions Mycobacterium smegmatis cultured in minimal medium (MM) has been used to induce cholesterol consumption in vitro. During cultivation, M. smegmatis con-sumes MM cholesterol and...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025783 | Pride
Mycobacterium  proteomics  cholesterol  infection  macrophages. 
ProteomicsProteome profile of Perkinsus marinus
Perkinsus marinus is an intracellular parasitic protozoan that is responsible for serious disease epizootics in marine bivalve molluscs worldwide and along with P. olseni belongs to the OIE list of notified diseases. Despite all available information on P. marinus genomics, more baseline data is req...
ORGANISM(S): Perkinsus marinus 
2018-01-08 | PXD003727 | Pride
In vitro culture Virulence Crassostrea rhizophorae Perkinsus marinus Label-free shotgun hdms 
ProteomicsInhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Background: The expression of MDM4, a well-known p53-inhibitor, is positively associated with chemotherapy response and overall survival in epithelial ovarian cancer (EOC). The basis of this association remains elusive. Since the occurrence of metastasis is one of the factors responsible for the hig...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-27 | PXD019935 | Pride
Ovarian cancer Mdm4 3d cell culture 
ProteomicsSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
The ubiquitin system regulates eukaryotic physiology by modifying specific substrate proteins. Substrate recruitment and the assembly of ubiquitin signals are determined by ubiquitin ligases, some of which also modify non-protein biomolecules. Here we expand this substrate realm, revealing that the ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD066563 | Pride
Small-molecule inhibitor Hect e3 Mass spectrometry Enzymology Click chemistry Non-protein ubiquitination 
ProteomicsQuantitative proteomics of human pancreatic beta cells
Outline: using label-free alternate-scanning LC-MS/MS, we compared the proteomic architecture of core functional pathways in pancreatic beta cells of human origin. Results: we quantified the relative molar abundance of 707 proteins mainly composed of functional pathways of metabolism, protein synthe...
ORGANISM(S): Homo sapiens (Human) 
2015-08-07 | PXD001539 | Pride
Human Lcmse Diabetes Biomarker Proteomics Islet beta cell Pancreas 
ProteomicsProfiling the proteome of Mycobacterium tuberculosis during dormancy and reactivation
Tuberculosis, caused by Mycobacterium tuberculosis, still remains a major global health problem. The main obstacle in eradicating this disease is the ability of this pathogen to remain dormant in macrophages, and to get reactivated later under immuno-compromised conditions. The physiology of hypoxic...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2015-06-01 | PXD001158 | Pride
Lc-msms Mycobacterium tuberculosis Dormancy Reactivation Quantitative proteomics 
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