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ProteomicsBiochemical and Structural Basif for Differential Inhibitor Sensitivity of EGFR with Distinct Exon 19 Mutaions
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We studied structural basis of differential TKI sensitivity among EGFR exon 19 mutants by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037374 | Pride
Exon 19 Hdx-ms Egfr 
ProteomicsA nature-inspired nanoplatform for multiple targeted proteins degradation via autophagy-lysosome pathway
This project primarily investigates the interactome of SNX18, a key mediator protein in the degradation of extracellular vesicles (EVs), as well as the degradation efficiency of EGFR and PDL1 using an SNX18-LIR motif-based overexpression platform for targeted protein degradation.
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072326 |
ProteomicsPPARgamma regulates a cell-to-cell communication program in human methastatic melanoma cells
We mapped the proteins secreted by A375 melanoma cells in the presence or absence of the PPARagonist rosiglitazone.
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD009108 | Pride
Rosiglitazone Melanoma Ppar Label-free quantitation Secretome 
ProteomicsProxiomes of the greenbeard proteins SmDOC1 and SmDOC2 in the filamentous fungus Sordaria macrospora
In this study, we used the in vivo proximity labeling biotin identification (BioID; Roux et al., 2012) method to capture proteins of the microenvironment of the greenbeard determinant of communication (DOC) proteins SmDOC1 and SmDOC2 in the filamentous fungus Sordaria macrospora. The genes Smdoc1 (S...
ORGANISM(S): Sordaria macrospora 
2026-08-19 | PXD069539 | Pride
Sordaria macrospora Turboid Proximity labeling Bioid Determinant of communication 
ProteomicsThe structural dynamics of EGFR exon 19 mutants
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). TKI responses vary across tumors driven by the heterogeneous group of exon 19 deletions and mutations, but the mole...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037355 | Pride
Exon 19 Hdx-ms Egfr 
ProteomicsEngineering consortia by polymeric microbial swarmbots
Synthetic microbial consortia represent a new frontier for synthetic biology given that they can solve more complex problems than monocultures. However, most attempts to co-cultivate these artificial communities fail because of the ‘‘winner-takes-all’’ in nutrients competition. In soil, multiple spe...
ORGANISM(S): Escherichia coli 
2022-07-04 | PXD034417 | Pride
Synthetic microbial consortia  spatial segregation  polymeric microcapsules  division of labor  communication 
ProteomicsThe strutural dynamics of EGFR Exon 19 mutants
Tyrosine kinase inhibtors are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We characterized the dynamics of purified EGFR exon 19 kinase domain mutants by HDX-MS with or withour erlotinib, one of th...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037448 | Pride
Hdx-ms Egfr Exon19 
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD001809 | Pride
Focal adhesions Integrin Extracellular matrix Msc Cell adhesion 
ProteomicsDefective NADPH Production in Mitochondrial Disease Complex I Causes Inflammation and Cell Death
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018839 | Pride
Human Mitochondria Tmt Nature communication manuscript: ncomms-19-24220b 
ProteomicsExtracellular vesicles are crucial mediators in orchestrating brain development and disease
Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiologica...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD028438 | Pride
Cerebral organoids Neurodevelopmental disease Lc-msms Brain development Extracellular vesicles Cstb 
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