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To identify protein partners of ataxin-1 in neuronal cells under control or stress conditions, we use complementary proteomics strategies of proximity-dependent biotin identification (BioID) and affinity purification (via GFP-trap pulldown) in Neuro-2a cells expressing epitope-tagged forms of ataxin...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010352 | Pride
Microarray analysis of RNA stability in mouse Neuro-2A cells
ORGANISM(S): Mus musculus 
Cadmium is a neurotoxic compound which induces cognitive alterations similar to those produced by Alzheimer's disease (AD). Autophagic flux impairment is a hallmark in Cd-induced AD-like pathology. However, the underlying mechanism remains obscure. In these study, Neuro-2a cells were exposed to diff...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD048158 | Pride
Viral infection of the central nervous system (CNS) is linked to neurodegenerative processes, but the metabolic mechanisms influencing antiviral responses and neuroinflammation remain poorly understood. Nicotinamide adenine dinucleotide (NAD) plays a key role in mitochondrial function and immune sig...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-29 | PXD075207 | Pride
Anandamide, or N-arachidonoylethanolamine (AEA), is a signaling lipid that modulates neurotransmitter release via activation of the cannabinoid receptor type 1 (CB1R) in the brain. Termination of anandamide signaling is thought to be mediated via a facilitated cellular reuptake process utilizing an ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD031488 | Pride
RNAseq of wild type and GDF11-/- Neuro-2a cells
Identification of the binding DNA of ONECUT2 by ChIP in Neuro-2a cells
Pax3 plays a role in Neuro-2a cells proliferation and neurite outgrowth
Alzheimer's disease (AD) is a progressive and irreversible neurological disorder which impairs the living quality of old people and even life spans. New compounds have shown potential inneuroprotective effects in AD, such as GFKP-19, which is a 2-pyrrolidone derivative, which has been proved to enha...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-16 | PXD005312 | Pride
This project studies a compound, which induces potent neuronal differentiation, by using iTRAQ-based proteomic analysis in Neuro-2a progenitor cells.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-19 | PXD009180 | Pride
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