Sort   by:  
 Page size 
ProteomicsUncovering Global Non-Covalent SUMO Binder Networks Reveals that Sumoylation enhances XRCC4 activitythe stabilization of the classical Non Homologous End Joining complex.
In contrast to our extensive knowledge on covalent SUMO target proteins, we are limited in our understanding of proteins that bind SUMO family members in a non-covalent manner. We have identified interactors of different SUMO isoforms: monomeric SUMO1, monomeric SUMO2 or linear trimeric SUMO2 chains...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD022924 | Pride
Non homologous end joining Sumo Xrcc4 Proteomics 
ProteomicsZinc finger protein ZNF384 is an adaptor of KU to DNA during classical non-homologous end-joining
DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damages as they can lead to mutations and chromosomal rearrangements, which underlie cancer development and progression. Non-homologous end-joining (NHEJ) is the dominant pathway for the repair of DSBs in human cells, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD020417 | Pride
Non homologous end joining  double strand break repair 
ProteomicsATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Mutations in the ATM tumor suppressor gene confer cellular hypersensitivity to various DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms towards such drugs, we performed genome-wide CRISPR-Cas9 loss-of-function screens in cells treated with the DNA topoisomerase I poison...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011108 | Pride
Atm Dna damage response 
GenomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
PRJNA1255162 | ENA
GenomicsTranscriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
Transcriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
PRJNA558142 | ENA
GenomicsDROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end-joining
DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end-joining
PRJNA701448 | ENA
GenomicsSETMAR functions in illegitimate DNA recombination and non-homologous end joining repair
SETMAR functions in illegitimate DNA recombination and non-homologous end joining repair
PRJNA533076 | ENA
GenomicsDNA-PKcs-dependent Non-homologous End Joining Repair Contributes to Ferroptosis Inhibition
DNA-PKcs-dependent Non-homologous End Joining Repair Contributes to Ferroptosis Inhibition
PRJNA1304505 | ENA
ProteomicsASF1 acts with RIF1 to promote DNA end-joining in BRCA1 deficient cells
RIF1 acts downstream of 53BP1 to coordinate DNA double strand break repair pathway choice between non-homologous end joining (NHEJ) and homologous recombination (HR). Here we identified ASF1 as an endogenous RIF1-associated protein. We showed that ASF1 forms complex with RIF1 and regulates RIF1-depe...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027727 | Pride
Rif1 Tap-ms Asf1 Interactome 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024695 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
Sort   by:  
 Page size