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ProteomicsLongitudinal plasma Olink Target 96 proteomics in Lyme disease
Plasma affinity proteomics from a longitudinal Lyme disease study was acquired in two phases using five Olink Target 96 panels. In the first phase, Inflammation and Immune Response panels were used to profiled patient and control samples across study visits (T1, diagnosis; T2, approximately 2-3 week...
ORGANISM(S): Homo sapiens (Human) 
2026-10-16 | PAD000065 | Pride
Lyme disease Affinity proteomics Human plasma Proximity extension assay Olink target 96 Longitudinal study 
ProteomicsLongitudinal Olink affinity proteomics profiling of cytokine release syndrome in myeloma patients receiving BCMA-directed CAR-T therapy
This submission contains de-identified Olink NPX affinity proteomics data from longitudinal peripheral blood samples collected from patients with relapsed/refractory multiple myeloma treated with BCMA-directed CAR-T therapy (ide-cel or cilta-cel) in a prospective single-center pilot study. Samples w...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PAD000041 | Pride
Car-t Myeloma Wearables Cytokines Crs 
ProteomicsTargeted Plasma Proteomics Reveals a Central Role of Upregulated TNFRSF Proteins in HIV-associated Stroke: A Cross-sectional Discovery and Longitudinal Validation Study
This study investigated circulating proteomic signatures associated with stroke in people with HIV (PWH) using a nested case–control design. Plasma samples were collected from 135 HIV-positive individuals with stroke (HIV+/Stroke+), 135 HIV-positive stroke-free controls (HIV+/Stroke−), and 135 HIV-n...
ORGANISM(S): Homo sapiens (Human) 
2026-06-06 | PAD000032 | Pride
Stroke People with hiv Olink 
ProteomicsCooking methods affect Advanced Glycation End products and lipid profiles: a randomized cross-over study in healthy subjects
Thermal treatments used in Ultra-Processed Foods (UPFs) lead to advanced glycation end products (AGEs) in food products. UPFs and serum AGEs are both associated with cardiometabolic disease. We explored differential cooking methods as a mechanistic link between UPFs and detrimental health outcomes. ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD059624 | Pride
Human Diet Olink 
ProteomicsInflammatory protein profiling shows limited ability to distinguish sepsis from sepsis mimics
This dataset contains normalized protein expression (NPX) measurements for 92 inflammatory proteins in 80 adult participants selected from four prospective cohorts in Japan for a retrospective case-control study. The primary comparison included 34 participants with sepsis and 46 with sepsis mimics: ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-22 | PAD000067 | Pride
Inflammatory proteins Serum Edta plasma Sepsis Proximity extension assay Sepsis mimics Olink Diagnostic discrimination 
ProteomicsMajor depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases
This dataset contains normalized protein expression (NPX) values from Olink proteomic profiling of serum from patients with major depressive disorder, atopic dermatitis, psoriasis, and healthy controls, using the proximity extension assay technology across four panels: Target 96 Inflammation, Cardio...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PAD000024 | Pride
Skin Depression Inflammation Immune 
ProteomicsTIMEPOINT, a phase 1 study of MTL-CEBPA in combination with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumours.
Many cancer patients don’t benefit from currently-approved immune checkpoint inhibitors (ICI), suggesting that additional immunomodulation of the immunosuppressive tumour microenvironment (TME) is required. MTL-CEBPA specifically upregulates expression of master myeloid transcription factor, CEBPA, ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060726 | Pride
Human Cancer Plasma proteome Immunomodulatory 
ProteomicsBaseline Plasma Proteomic Profiling Associated with Response to Immune Checkpoint Inhibitor-Based Chemoimmunotherapy in Non-Small Cell Lung Cancer
This study aimed to identify candidate plasma protein biomarkers associated with response to immune checkpoint inhibitor (ICI)-based chemoimmunotherapy in patients with advanced non-small cell lung cancer (NSCLC). Although ICI-based chemoimmunotherapy has become an important treatment strategy for a...
ORGANISM(S): Homo sapiens 
2026-10-20 | PAD000066 | Pride
Non-small-cell lung cancer Immune checkpoint inhibitors 
UnknownSynthetic plasma pool cohort correction for affinity-based proteomics datasets allows multiple study comparison.
Not available
S-EPMC11653412 | biostudies-literature
ProteomicsTechnical evaluation of human plasma proteomics methods
In our study, seven plasma proteomics methods were evaluated including five MS-based protocols (Neat (Untreated), TOP14 depletion (Thermo Scientific), Enrich (PreOmics, part of Bruker now), PCA-N (Mann’s protocol + ref) and Proteograph XT (Seer)) and two antibody-based ones (Olink Target Inflammatio...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070072 | Pride
Plasma Depletion Affinity-based proteomics Enrichment Mass spectrometry Proteomics 
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