Sort   by:  
 Page size 
ProteomicsEvaluating the performance of photon- and electron-based fragmentation methods in Omnitrap-LCMS analysis of N-glycopeptides
To date, collision-induced dissociation and methods based on electron transfer dissociation are considered the standard approaches for the mass spectrometry analysis of N- and O-glycopeptides, respectively, allowing for identification of both peptide and glycan compositions. In recent years, alterna...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD071023 | Pride
Glycopeptides Omnitrap Ecd Uvpd Eid 
MetabolomicsIsotope tracing-based metabolite identification for mass spectrometry metabolomics

Modern mass spectrometry-based metabolomics is a key technology for biomedicine, enabling discovery and quantification of a wide array of biomolecules critical for human physiology. Yet, only a fraction of human metabolites have been structurally determined, and the majority of features in typica...

2025-08-15 | MTBLS12861 | MetaboLights
Proteomics(LCMS)/MS studies of prefrontal cortex synaptosomal fractions in Eef2 HET mice - eEF2 in the prefrontal cortex regulates excitatory synaptic transmission and social novelty behavior.
To investigate the protein expression changes at the synapse induced by Eef2 reduction, we performed (LCMS)/MS-based proteomic analysis in crude synaptosome preparations from the PFC of WT and Eef2 HET mice.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD034864 | Pride
Prefrontal cortex (lcms)/ms Synaptosome Eef2 
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
ProteomicsLCMS quantification of internal crosslink in WT and G68L mutant R2lox proteins from Geobacillus kaustophilus.
A heterobimetallic Mn/Fe cofactor is found in the R2 subunit of class Ic ribonucleotide reductases (R2c) and R2-like ligand-binding oxidases (R2lox). Although the protein-derived metal ligands are the same in both groups of proteins, the connectivity of the two metal ions and the chemistry each cofa...
ORGANISM(S): Geobacillus kaustophilus 
2019-10-31 | PXD015549 | Pride
Ferritin  metalloprotein  ribonucleotide reductase  r2-like ligand-binding oxidase  r2lox  crosslink 
ProteomicsLCMS spermatozoa and seminal plasma
This dataset contains raw and processed LC–MS/MS data from a paired proteomic analysis of seminal plasma and spermatozoa fractions obtained from the same ejaculates of two adult stallions. Samples were analyzed using a Vanquish nanoLC system coupled to an Orbitrap Exploris 240 mass spectrometer oper...
ORGANISM(S): Equus caballus (Horse) 
2026-05-21 | PXD074771 | Pride
Seminal plasma Exploris240 Ecuus qabalus Spermatozoa 
ProteomicsQuantitative analysis of protein ubiquitination
Protein ubiquitination orchestrates nearly all eukaryotic cellular events.1 It starts by attaching ubiquitin through isopeptide bonds to a single or multiple lysine residues of a target protein via a coordinated enzymatic reaction involving activating (E1), conjugating (E2), and ligating (E3) enzyme...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037416 | Pride
Ibaq-ub Ubiquitination Stoichiometry Lcms Quantitative proteomics 
ProteomicsStop trashing your spectra! Use a “Quantify then Identify” pipeline based on machine learning to maximize your isobaric tagging data
Being inspired by metabolomic data processing, we have developed a bioinformatic pipeline that optimizes the processing of mass spectral data obtained from isobaric Tandem Mass Tag (TMT) experiments. Our method focuses on the tandem mass spectral level by first quantifying and then identifying (QtI)...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-05-01 | PXD005206 | Pride
Plasma Isobaric tagging Tmt Human Lc-ms Csf 6-plex Orbitrap 
MetabolomicsGanhai Weikang Capsules Improve Functional Dyspepsia in Rats by Modulating Gut Microbiota and Host Metabolism
The chemical constituents of GHWKCs were identified using UPLC-LTQ-Orbitrap-MS, and untargeted metabolomics analysis was performed on the duodenum of the model rats.
2026-07-16 | MTBLS14314 | MetaboLights
Sort   by:  
 Page size