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ProteomicsMultidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal and malignant urothelial cells
Epigenetic regulators, such as the SWI/SNF complex, play an important role in tissue development and homeostasis, and are frequently mutated in cancer. ARID1A, a subunit of the SWI/SNF complex, is mutated in approximately 20% of all bladder tumors, however, our understanding of the consequences ther...
ORGANISM(S): Homo sapiens (Human) 
2025-03-02 | PXD054817 | Pride
Human Ap-ms Urothelial cell lines 
TranscriptomicsEarly response of gene expression in the distal intestine of Atlantic salmon (Salmo salar L.) during the development of soybean meal induced enteritis
In the present study a 44k oligonucleotide salmonid microarray, qPCR and histology were used to investigate transcriptomic responses in the distal intestine during the first week of oral exposure to soybean meal in order to gain insight into early molecular response mechanisms. Intestinal tissue sam...
ORGANISM(S): Salmo salar 
2012-12-17 | E-GEOD-37457 | biostudies-arrayexpress
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella Homo sapiens (Human) Morganella Pseudomonas sp. 
2015-02-17 | PXD000164 | Pride
Metaproteomics 
ProteomicsBiomarkers of hepatocellular synthesis predict mortality in patients with decompensated cirrhosis
Background & Aims: Since liver hepatocytes produce the majority of serum proteins, liver cirrhosis displays a massive alteration in serum proteome. The aim of the current study was to characterize these alterations and to study the prognostic usefulness of hepatocellular proteins available in routin...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD035024 | Pride
Biomarker Serum Human Cirrhosis Lc-ms/ms 
ProteomicsReceptor kinase pathway signal tuning through a non-transcriptional incoherent feedforward loop
This project investigated an auto-regulatory feedback in a plant receptor kinase pathway: The signaling of the endogenous CLAVATA3/EMBRYO SURROUNDING REGION 45 (CLE45) peptide via the receptor kinase BARELY ANY MERISTEM 3 (BAM3) in Arabidopsis (Arabidopsis thaliana) vascular development. Downstream,...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-28 | PXD061525 | Pride
Cle45 Receptor kinase Bam3 Arabidopsis Makr5 
ProteomicsAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status and is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. However, the precise mechanisms by which AMPK contro...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD009968 | Pride
Human Autophagy Nanolc-msms Phosphorylation 
TranscriptomicsTranscription profiling of human carcinoma in situs cells from testis compared to fetal gonocytes, oogonia and cultured embryonic stem cells
Abstract: Testicular cancers in young adult men derive from an inborn precursor lesion, called carcinoma in situ (CIS) of the testis. CIS cells are believed to arise from primordial germ cells or gonocytes that fail to differentiate into the male germ cell lineage, and show a remarkable resemblance ...
ORGANISM(S): Homo sapiens 
2009-06-15 | E-TABM-488 | biostudies-arrayexpress
ProteomicsNeuralized-like protein 4 (Neurl4) mediates ADP-ribosylation of mitochondrial proteins
Characterization of NEURL4 as a novel mitochondrial ART enzyme and identification of its potential targets.
ORGANISM(S): Homo sapiens (Human) 
2022-02-04 | PXD029538 | Pride
Mitochondrial proteins Hela Neurl4 Adp-ribosylation Mitochondrial art 
ProteomicsStructural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation
The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity towards lipids or endo- and exonuclease activity towards nucleic acids. PLD3 is synthesized as a type II transmembrane protein and proteolytically cleaved in lysosomes yielding a soluble active form. The deficien...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-24 | PXD044504 | Pride
Lysosome Phospholipase d Structural biology Dna/rna degradation 5' exonuclease Pld3 
ProteomicsProteomics of cassava storage roots before and after shoot pruning
Cassava (Manihot esculenta Crantz) is a food security crop for approximately 800 million people, primarily in developing economies. Cassava root yield is determined by the allocation of photoassimilated carbon within the plant, yet there is limited molecular and biochemical information about source-...
ORGANISM(S): Manihot esculenta (Cassava) (Jatropha manihot) 
2026-04-01 | PXD045690 | Pride
Manihot esculenta Storage roots Pruning Cassava 
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