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TranscriptomicsTranscriptional profiling of rat heart ventricular myocytes treated either with PD184352 alone or PD184352 and endothelin-1.
Effects of PD184352 on RNA profiles in neonatal rat cardiomyocytes exposed to endothelin-1
ORGANISM(S): Rattus norvegicus 
2010-05-26 | E-MEXP-2516 | biostudies-arrayexpress
TranscriptomicsIdentification of direct transcriptional targets of V600EBRAF/MEK in melanoma
A375P melanoma cells were treated with 1uM of the MEK inhibitor PD184352 or 0.4uM of the V600EBRAF inhibitor PLX4720 for 2hr, 6hr and 24hrs. DMSO treatment for 2hr, 6hr and 24hrs serves as the negative control Triplicate experiments were performed for DMSO, PD184352 and PLX4720 treatment at 3 timepo...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17089 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Rattus norvegicus cardiomyocytes to investigate the effects of PD184352 and BI-D1870 on changes in expression induced by endothelin-1
Cardiomyocytes were exposed to PD184352, BI-D1870 or endothelin-1 alone, or to endothelin-1 in the presence of each inhibitor
ORGANISM(S): Rattus norvegicus 
2013-01-16 | E-MEXP-3679 | biostudies-arrayexpress
UnknownMEK-inhibitor PD184352 enhances the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922: the role of cell type and drug-irradiation schedule.
Not available
S-EPMC6324777 | biostudies-literature
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 6
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087955 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087954 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 3
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087953 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 4
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087952 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087949 | MassIVE
ProteomicsLC-MS analysis of human melanoma cell line response to eIF4F inhibition and MEK inhibition
The project aimed to identify changes at the protein level in human melanoma cells treated with the eIF4F inhibitor rocaglamide A, the MEK inhibitor PD184352 (CI-1040), and their combination. A375 and MelJuso human melanoma cell lines were cultured in RPMI 1640 medium supplemented with 10% fetal bov...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD073251 | Pride
Eif4a Human Inhibitor Rocaglamide a Small-molecule Ci-1040 Melanoma Pd184352 Cell line Meljuso A375 Lc-ms Eif4f Mek 
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