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GenomicsSequences Associated with Centromere Competency in the Human Genome
Centromeres, the sites of spindle attachment during mitosis and meiosis, are located in specific positions in the human genome, normally coincident with diverse subsets of alpha satellite DNA. While there is strong evidence supporting the association of some subfamilies of alpha satellite with centr...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-45497 | biostudies-arrayexpress
GenomicsComposition and organization of active centromere sequences in complex genomes
We report the sequences bound to CENP-A in the dog genome (Canis familiaris) for high-throughput characterization of centromeric sequences. We compare these ChIPSeq reads (72 bp, single read) against a reference centromeric satellite DNA domain database for the dog genome, resulting in the annotatio...
ORGANISM(S): Canis lupus familiaris 
2012-07-23 | E-GEOD-38079 | biostudies-arrayexpress
TranscriptomicsGenomic and genetic characterization of rice Cen3 reveals evolutionary remnants of a complex centromere (mRNA data)
The centromere is the chromosomal site for assembly of the kinetochore where spindle fibers attach during cell division. In most muticellular eukaryotes, centromeres are composed of long tracks of satellite repeats that are recalcitrant to sequencing and fine scale genetic mapping. Here we report ...
ORGANISM(S): Oryza sativa 
2006-05-26 | E-GEOD-4920 | biostudies-arrayexpress
TranscriptomicsMyb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast
The TTAGGG motif is common to two seemingly unrelated dimensions of chromatin function M-^V the vertebrate telomere repeat and the promoter regions of many Schizosaccharomyces pombe genes, including all of those encoding canonical histones. The essential S. pombe protein Teb1 contains two Myb-like D...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-14 | E-MTAB-1253 | biostudies-arrayexpress
TranscriptomicsGenomic and genetic characterization of rice Cen3 reveals evolutionary remnants of a complex centromere (small RNA data)
The centromere is the chromosomal site for assembly of the kinetochore where spindle fibers attach during cell division. In most muticellular eukaryotes, centromeres are composed of long tracks of satellite repeats that are recalcitrant to sequencing and fine scale genetic mapping. Here we report ...
ORGANISM(S): Oryza sativa 
2006-05-26 | E-GEOD-4912 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35524 | biostudies-arrayexpress
ProteomicsRio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
Kinetochores assemble on centromeres via histone H3 variant CENP-A and low levels of noncoding centromere transcripts (cenRNAs). The latter are ensured by transcription factor Cbf1 (S. cerevisiae), centromere-binding protein CENP-B (humans), and the local histone code downregulating RNA polymerase I...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD038337 | Pride
Rat1 Kinetochore Centromere Per centromere Riok1 Rio1 
Unknown"Point" centromeres of Saccharomyces harbor single centromere-specific nucleosomes.
Not available
S-EPMC3316665 | biostudies-literature
TranscriptomicsSlx5_Slx8_Genome_Stability
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of ubiquitin ligases (STUbLs) that target sumoylated substrates. Slx5/8 has been implicated in genome stability and transcription, but the precise contribution to these processes is not clear. To character...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-06 | E-GEOD-33929 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres
This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress
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