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MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
ProteomicsDeciphering changes to human platelet proteome and degradome during storage before transfusion
Proteases, and specifically metalloproteinases, have been linked to the loss of platelet function during storage before transfusion, albeit the mechanism remains unknown. We used a dedicated N-terminomics technique, multiplex iTRAQ-TAILS (Terminal Amine Isotope Labeling of Substrates), to characteri...
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD000906 | Pride
Platelets Metalloproteinases Degradome Proteases Tails Human Ls-msms 
ProteomicsPlatelet proteome dynamics in hibernating 13-lined ground squirrels
Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor and must suppress hemostasis to avoid stasis blood clotting. In addition, cold storage of most mammalian platelets induces cold storage lesions, resulting in rapid clearance following transfusion. 13-lined ground...
ORGANISM(S): Ictidomys tridecemlineatus arenicola 
2021-12-08 | PXD026903 | Pride
Platelets Platelet cold storage Psr-ohsu Platelet transfusion Hibernation Torpor Tmt labeling Quantitative proteomics 
ProteomicsProteome analysis of human serum and plasma under the different pre-analytical processing
The storage conditions after collecting blood are expected to influence blood proteome. The present project assessed the differences in proteome between human serum and plasma, and stability of human plasma proteins under different storing duration at room temperature (0-30 min) and cold temperature...
ORGANISM(S): Homo Sapiens (human) 
2020-03-23 | PXD014305 | JPOST Repository
UnknownDivalent magnesium restores cytoskeletal storage lesions in cold-stored platelet concentrates.
Not available
S-EPMC9010418 | biostudies-literature
UnknownEarly Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.
Not available
S-EPMC11224567 | biostudies-literature
UnknownEarly Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial.
Not available
S-EPMC11974628 | biostudies-literature
UnknownCold storage conditions modify microRNA expressions for platelet transfusion.
Not available
S-EPMC6608970 | biostudies-literature
UnknownCold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates.
Not available
S-EPMC6312032 | biostudies-literature
UnknownImproved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.
Not available
S-EPMC3590094 | biostudies-literature
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