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TranscriptomicsThe Sp100 component of ND10/PML bodies is a potent tumor suppressor
The Sp100 component of ND10/PML bodies is a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. Identifying the functions of proteins, which define specific subnuclear structures and territorie...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-20613 | biostudies-arrayexpress
TranscriptomicsIdentifying chromatin associations with promyelocytic leukemia nuclear bodies using immunoTRAP
Studies using fluorescence in situ hybridization (FISH) have attempted to determine whether specific gene loci associate with promyelocytic leukemia nuclear bodies (PML NBs). Two drawbacks accompany this approach; the lack of spatial resolution inherent with the technique, and the a priori basis fo...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-40554 | biostudies-arrayexpress
ProteomicsPML Nuclear Bodies are stress-responsive sumoylation/degradation compartments regulating KAP1 silencing function in embryonic stem cells
PML drives the assembly of PML Nuclear Bodies (NBs), where it recruits many serendipitously-identified proteins, including the SUMO-E2 enzyme UBC9. Interferons, arsenic or oxidative stress, all enhance NB-formation. Here demonstrate that PML is required for efficient basal sumoylation in mouse embry...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-14 | PXD019609 | Pride
Transposable elements Embryonic stem cells Stress Dppa2 Pml nuclear bodies Arsenic Sumoylation Ubiquitin Acute promyelocytic leukemia Kap1-trim28-tif1b 
ProteomicsUnbiased in vivo exploration of nuclear bodies-enhanced sumoylation reveals that PML orchestrates embryonic stem cell fate (II)
Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation, but their role in pluripotency remains elusive. Here we establish that PML is required...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-06 | PXD032240 | Pride
Proteomics Sumo Pml 
ProteomicsProximity labelling with TurboID shows that client proteins of PML NBs differ in three cell contexts
PML nuclear body (PML NB) recruits different client proteins under different cell context. We used TurboID proximity labeling (PL) method followed by MS to determine the composition of PML NBs in mESCs, differentiated cells, and NaAsO2-treated mESCs.
ORGANISM(S): Mus musculus (Mouse) 
2023-01-10 | PXD037432 | Pride
Pml Differentiation Mesc Turboid Naaso2 
GenomicsSp100A isoform induces the histone chaperone, HIRA to localize to PML nuclear bodies
Sp100A isoform induces the histone chaperone, HIRA to localize to PML nuclear bodies
PRJNA1230702 | ENA
ProteomicsUnbiased in vivo exploration of nuclear bodies-enhanced sumoylation reveals that PML orchestrates embryonic stem cell fate
Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation, but their role in pluripotency remains elusive. Here we establish that PML is required...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-14 | PXD028865 | Pride
Pml Cancer Sumo Embryonic stem cells 
GenomicsPaediatric Glioma Histone H3.3 K27M/G34R Mutations Drive Abnormalities in Phase-Separated PML Nuclear Bodies.
Paediatric Glioma Histone H3.3 K27M/G34R Mutations Drive Abnormalities in Phase-Separated PML Nuclear Bodies.
PRJNA864751 | ENA
TranscriptomicsRole of PML in repression of transposable elements and in embryonic stem cell fate
Microarrays transcriptomic data analyses from 3 Pml-/- and 3 Pml+/+ mESCs samples
ORGANISM(S): Mus musculus 
2022-02-01 | E-MTAB-10151 | biostudies-arrayexpress
GenomicsRecruitment of TRIM33 to cell-context specific PML nuclear bodies regulates Nodal signaling in mESCs
Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates Nodal signaling in mESCs
PRJNA821409 | ENA
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