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ProteomicsMass spectrometry approach to identify mitochondrial poly(A) RNA interacting proteins
To identify mitochondrial RNA-interacting proteins, we developed three related mass spectrometry based methods. In the first method, called mitochondrial crosslinking (MXL), mitochondria of 4-thiouridine labelled cells were isolated, exposed to UV-light and poly(A) RNA was isolated. In the second me...
ORGANISM(S): Homo sapiens (Human) 
2019-10-15 | PXD014957 | Pride
Mitochondrial rna Mass spectrometry 4-thiouridine labelling & crosslinking 
ProteomicsProximity proteomics of C9orf72 dipeptide repeat proteins
Profiling of proximity proteomes of C9orf72-derived dipeptide repeat proteins (poly-GA, poly-GR, poly-PR) in HEK293 cells using BioID assay
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-17 | MSV000088581 | MassIVE
ProteomicsTherapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I:C) - stimulated macrophages
Macrophages plasticity is a key feature in cancer progression. Neoplastic cells can alter their immune functions and orient them into a pro-tumoral phenotype. In this context and based on our previous work, we developed a new therapeutic strategy to switch macrophages phenotype and reactivate their ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-23 | PXD020258 | Pride
Glioma Rat Macrophages Reactivation Proprotein convertases Poly (i:c) 
ProteomicsTranslation deficits drive C9orf72 associated poly-GR/PR toxicity
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients with the C9orf72 mutation show predominantly cytoplasmic aggregates of poly-GR and poly-PR proteins that are acutely toxic in various model systems. To identify the molecular mediators of neurotoxicity of poly-GR/PR, we a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-06-27 | PXD008691 | Pride
Ftld Proteomics Stress granules Als Ribosome Nucleolus Dpr proteins Interactome C9orf72 Translation 
ProteomicsPoly(A) binding KPAF4/5 in Trypanosoma brucei
Raw file submission for publication 'Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei'
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2020-03-27 | MSV000085175 | MassIVE
ProteomicsEffect of heat-shock on total, poly-ubiquitylated, and insoluble proteomes of human IMR-90 fibroblasts in different proliferation states
Cellular stress responses are crucial for survival in sub-optimal conditions, and almost invar-iably involve proteome-wide alterations at the levels of protein abundance, post-translational modification with poly-ubiquitin chains (poly-ubiquitylation), and solubility. However, most of our understand...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD067225 | Pride
Human Lc-msms Proteostasis Quiescence Insoluble Lung Stress Senescence Heat-shock Fibroblast Ubiquitin Aggregate 
ProteomicsEffect of proteasome inhibition on total and poly-ubiquitylated proteomes of human A549 lung adenocarcinoma cells in different proliferation states
Cellular stress responses are crucial for survival in sub-optimal conditions, and almost invar-iably involve proteome-wide alterations at the levels of protein abundance and post-translational modification with poly-ubiquitin chains (poly-ubiquitylation). However, most of our understanding of human ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD067220 | Pride
Human Proteostasis Insoluble Lung Cancer Ubiquitin Aggregate Lc-msms Bortezomib Stress Senescence Epithelia Pro-teasome 
ProteomicsEffect of heat-shock on total and poly-ubiquitylated proteomes of human A549 lung adeno-carcinoma cells in different proliferation states
Cellular stress responses are crucial for survival in sub-optimal conditions, and almost invar-iably involve proteome-wide alterations at the levels of protein abundance and post-translational modification with poly-ubiquitin chains (poly-ubiquitylation). However, most of our understanding of human ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD067153 | Pride
Human Lc-msms Proteostasis Insoluble Lung Stress Cancer Senescence Heat-shock Epithelia Ubiquitin Aggregate 
ProteomicsThe RNA-binding ubiquitin ligase MKRN1 acts as a sensor for ribosome-associated quality control of poly(A)-translation
Human cells have evolved multiple quality control mechanisms to ensure protein homeostasis by detecting aberrant mRNAs and protein products which are condemned for rapid decay. Translating ribosomes that run into poly(A) tails are terminally stalled, followed by ribosome recycling and rapid decay of...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD011772 | Pride
Ubiquitylation Rna binding Ubiquitin remnant profiling Poly(a) Mkrn1 Iclip Ribosome-associated quality control 
ProteomicsPARG is Essential for Pol-theta-Mediated DNA End-Joining by Removing Repressive Poly-ADP Ribose Marks
DNA polymerase theta (Pol-theta)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Pol-theta is regulated at the molecular level to exert TMEJ remains unknown. We find that Pol-theta interacts with and is PARylated by PARP1 in vitro and in c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092839 | MassIVE
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