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To screen for genes involved in cold-acclimation in carp
ORGANISM(S): Cyprinus carpio 
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadCh...
ORGANISM(S): Homo sapiens 
Iron is an irreplaceable co-factor for important enzyme systems, and iron deficiency is the most common micronutrient deficiency worldwide. How iron deprivation influences normal cellular function remains poorly characterised. Using activated CD8+ T-cells as a model for dividing cells we show iron r...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-24 | PXD047814 | Pride
Development of red blood cells from progenitors requires profound reshaping of both gene expression and metabolism. How these processes are coupled is unclear. Nprl3, an inhibitor of mTORC1, has remained in synteny with the -globin genes for >500 million years, and harbours most of the -globin enha...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-12 | PXD060557 | Pride
In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to expl...
ORGANISM(S): Mus musculus 
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