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In this project, we investigated how the spliceosome bound to an excised intron-lariat is remodeled and how the associated intron-lariat is debranched during the process collectively known as spliceosome termination. We used a native pulldown from a C. elegans strain carrying an endogenous tag on th...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-08-19 | PXD081218 | Pride
This dataset comprises a tandem mass tag (TMT)–based quantitative proteomic analysis of proteins proximal to SYCP1 identified using BioID proximity labelling. Two independent BioID experiments were performed using distinct SYCP1 constructs: an N-terminal Myc-tagged SYCP1 and a C-terminal HA-tagged S...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD072359 | Pride
By employing a proximity labeling approach using Arabidopsis ATG8e tagged with TurboID as bait in atg2-1 background, we discovered a protein family of unknown function, consisting of two homologs (AT4G02880 and AT1G03290). Both proteins contain coil-coiled domains that are predicted to be closely re...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-07 | PXD067352 | Pride
This dataset supports a study investigating how the PDZ domain of Dishevelled-2 (DVL2) specifies β-catenin-independent Wnt signalling outputs. BioID proximity labelling was performed in HEK293 Flp-In T-REx cells stably expressing BirA*-tagged wild-type DVL2 or a matched DVL2 mutant lacking the PDZ d...
ORGANISM(S): Homo sapiens (Human) 
2026-09-12 | PXD079793 | Pride
FOXA1 is a pioneer transcription factor essential for chromatin accessibility and transcriptional regulation in hormone-driven cancers. In breast cancer, FOXA1 plays a central role in facilitating nuclear receptor binding, reprogramming enhancer landscapes, and promoting transcriptional changes asso...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE299760 | GEO
FOXA1 is a pioneer transcription factor essential for chromatin accessibility and transcriptional regulation in hormone-driven cancers. In breast cancer, FOXA1 plays a central role in facilitating nuclear receptor binding, reprogramming enhancer landscapes, and promoting transcriptional changes asso...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE287088 | GEO
This project contains LC-MS/MS proteomic data generated from an MS2-MCP-TurboID proximity labeling experiment designed to identify proteins enriched in the proximity of the Arid3a 3′UTR. Cells expressing MS2-tagged Arid3a 3′UTR and MCP-TurboID were subjected to biotin labeling, streptavidin enrichme...
ORGANISM(S): Homo Sapiens 
2026-06-23 | PXD080101 |
The transcription factor SOX10 is a central regulator of melanoma biology, influencing tumor initiation, progression, phenotypic plasticity, and therapeutic resistance. However, the molecular mechanisms underlying these diverse functions remain incompletely understood. To elucidate the protein-prote...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD067868 | Pride
Description Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We initially use a proximity-dependent biotinylation proteomics strategy to label protein that e...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015479 | Pride
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