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ProteomicsLight-sensing via H2O2 and a peroxiredoxin
Light controls control a vast array of biological processes, including cell and organelle motility, stress responses, organismal development and the entrainment of circadian rhythms, that maintain diurnal cycles of activity in organisms from cyanobacteria to humans. Recent studies indicate that a ty...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-07-03 | PXD001853 | Pride
Lc-msms Yeast H2o2 Oxidative stress Msn2 
ProteomicsCDK and MAPK collaborate to regulate signaling dynamics via multi-site phosphorylation of the scaffold protein Ste5
CDKs and MAPKs phosphorylate similar sites yet generally have distinct functions/substrates. We report here an unanticipated system of cooperative regulation by CDK and MAPK, involving collaborative multi-site phosphorylation of a single substrate. The budding yeast protein Ste5 is a signaling scaff...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-03-12 | PXD006154 | Pride
Yeast Cdk Phospho proteomics Mapk Ste5 Pheromone response 
ProteomicsExternal and intrinsic mechanical stress restricts pheromone signaling by direct phosphorylation of the Ste5 scaffold by Pkc1
Ste5 and Far1 function as prototypical scaffold proteins activating a MAP-kinase cascade and polarizing yeast cells in response to pheromones. Here we show that Pkc1-dependent phosphorylation of conserved serine residues in their RING-H2 domains down-regulates pheromone induced signaling upon mechan...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-17 | PXD004657 | Pride
Yeast Saccharomyces cerevisiae Scaffold Mapk Ste5 Far1 
ProteomicsNovel interconnections of HOG signaling revealed by combined use of two proteomic software packages
Modern quantitative mass spectrometry (MS)-based proteomics enables researchers to unravel signaling networks by monitoring proteome-wide cellular responses to different stimuli. MS-based analysis of signaling systems usually requires an integration of multiple quantitative MS experiments, which rem...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-11 | PXD011935 | Pride
Orm2 Hog1 P38 Mitogen-activated protein kinase (mapk) Hyperosmotic stress response Ormdl Maxquant High-osmolarity glycerol (hog) Kic1 Proteomics Proteome discoverer 
UnknownDissipative quantum error correction and application to quantum sensing with trapped ions.
Not available
S-EPMC5704006 | biostudies-literature
ProteomicsIdentifying protein kinase specific effectors of the osmostress response in yeast_part1
Saccharomyces cerevisiae reacts to elevated external osmolarity by several cellular responses. Thereby, the main adaptive signaling activity relies on the high-osmolarity glycerol (HOG) pathway, whose core architecture is closely related to the mammalian p38 MAPK pathway. To identify novel target pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-01 | PXD004294 | Pride
Rck2 Hog1 Yeast Ms shotgun Saccharomyces cerevisiae Mapk Kinase Phosphorylation 
ProteomicsIdentifying protein kinase specific effectors of the osmostress response in yeast_part6
Saccharomyces cerevisiae reacts to elevated external osmolarity by several cellular responses. Thereby, the main adaptive signaling activity relies on the high-osmolarity glycerol (HOG) pathway, whose core architecture is closely related to the mammalian p38 MAPK pathway. To identify novel target pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-01 | PXD004299 | Pride
Rck2 Hog1 Yeast Ms shotgun Saccharomyces cerevisiae Mapk Kinase Phosphorylation 
ProteomicsIdentifying protein kinase specific effectors of the osmostress response in yeast_part7
Saccharomyces cerevisiae reacts to elevated external osmolarity by several cellular responses. Thereby, the main adaptive signaling activity relies on the high-osmolarity glycerol (HOG) pathway, whose core architecture is closely related to the mammalian p38 MAPK pathway. To identify novel target pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-01 | PXD004300 | Pride
Rck2 Hog1 Yeast Ms shotgun Saccharomyces cerevisiae Mapk Kinase Phosphorylation 
ProteomicsIdentifying protein kinase specific effectors of the osmostress response in yeast_part4
Saccharomyces cerevisiae reacts to elevated external osmolarity by several cellular responses. Thereby, the main adaptive signaling activity relies on the high-osmolarity glycerol (HOG) pathway, whose core architecture is closely related to the mammalian p38 MAPK pathway. To identify novel target pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-01 | PXD004297 | Pride
Rck2 Hog1 Yeast Ms shotgun Saccharomyces cerevisiae Mapk Kinase Phosphorylation 
ProteomicsIdentifying protein kinase specific effectors of the osmostress response in yeast_part5
Saccharomyces cerevisiae reacts to elevated external osmolarity by several cellular responses. Thereby, the main adaptive signaling activity relies on the high-osmolarity glycerol (HOG) pathway, whose core architecture is closely related to the mammalian p38 MAPK pathway. To identify novel target pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-01 | PXD004298 | Pride
Rck2 Hog1 Yeast Ms shotgun Saccharomyces cerevisiae Mapk Kinase Phosphorylation 
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