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ProteomicsPatient-based model systems for AD
The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathog...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-10-24 | PXD042229 | Pride
Hippocampus Hippocampal graft Alzheimers disease 
UnknownMSIWarp: A General Approach to Mass Alignment in Mass Spectrometry Imaging.
Not available
S-EPMC7745203 | biostudies-literature
UnknownClusterwise Peak Detection and Filtering Based on Spatial Distribution To Efficiently Mine Mass Spectrometry Imaging Data.
Not available
S-EPMC6751525 | biostudies-literature
ProteomicsHuman brain Alzheimer's - Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder being characterized by progressive impairment of memory and cognition, resulting in dementia. To investigate brain region vulnerability to AD and which pathways are altered in certain areas in AD, we performed proteomic profiling...
ORGANISM(S): Homo sapiens (Human) 
2019-07-01 | PXD010138 | Pride
Qe Human brain Alzheimer's disease 
ProteomicsIn-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part II: cell media)
Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation bur...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD029821 | Pride
Sclc Proteomics Cell lines Molecular subtypes 
ProteomicsIn-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part I: cell pellets)
Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation bur...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD029805 | Pride
Sclc Proteomics Cell lines Molecular subtypes 
ProteomicsPhosphoproteomic analysis of induced neurons from patients with Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD055857 | Pride
Induced neurons Huntington disease 
ProteomicsProteomic changes linked to the limbic stage of AD
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout the brain cortex in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Here, we conducted proteomic, acet...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027173 | Pride
Neuroinflammation Proteomics Limbic stage Phosphoproteomics Alzheimer's disease 
ProteomicsHuman hippocampal spheroids for modelling AD
The hippocampus is important for memory formation and is severely affected in the brain with Alzheimer's disease (AD). Since AD brain tissue is available postmortem, our understanding of early pathogenic processes occurring in hippocampi remains speculative. Here, an MS-based proteomic approach was...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012524 | Pride
Ad Hippocampus Ipsc 
OtherA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues.
Data from ProteomeXchange, .PXD ID: PXD001724. Experiment: M35_003, file: folder summary. Published as part of PLoS One. 2015 Apr 13;10(4):e0123661 . From the Abstract: {{i}} ... The aim of the present study was to build a protein sequence database in metastatic melanoma, searching for novel, relev...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310019253 | GPMDB
Resource Reanalysis 
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