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ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
UnknownA Framework for Quality Control in Quantitative Proteomics.
Not available
S-EPMC11973981 | biostudies-literature
UnknownA framework for quality control in quantitative proteomics.
Not available
S-EPMC11030400 | biostudies-literature
ProteomicsImproved analysis of crosslinking mass spectrometry data with Kojak 2.0, advanced by integration into the Trans-Proteomic Pipeline
Fragmentation ion spectral analysis of chemically crosslinked proteins is an established technology in the proteomics research repertoire for determining protein interactions, spatial orientation, and structure. Here we present Kojak version 2.0, a major update to the original Kojak algorithm, which...
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) 
2023-01-18 | PXD037492 | Pride
Kojak Crosslinking mass spectrometry Proteomics Software tools Protein interaction Peptideprophet Xl-ms Trans-proteomic pipeline Computational proteomics Iprophet 
ProteomicsRpomeroyi DSS-3 - Whole organism, NSAF (Krayushkinaetal,scidata2019)
abundance based on NSAF, Interaction consistency score: 10.0, Coverage: 45
ORGANISM(S): 246200 
2019-00-00 | 611508931 | PAXDB
ProteomicsRpomeroyi DSS-3 - Whole organism, SC (Krayushkinaetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 9.3, Coverage: 38
ORGANISM(S): 246200 
2019-00-00 | 402674203 | PAXDB
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
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