Sort   by:  
 Page size 
ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
UnknownA Framework for Quality Control in Quantitative Proteomics.
Not available
S-EPMC11973981 | biostudies-literature
UnknownA framework for quality control in quantitative proteomics.
Not available
S-EPMC11030400 | biostudies-literature
ProteomicsImproved analysis of crosslinking mass spectrometry data with Kojak 2.0, advanced by integration into the Trans-Proteomic Pipeline
Fragmentation ion spectral analysis of chemically crosslinked proteins is an established technology in the proteomics research repertoire for determining protein interactions, spatial orientation, and structure. Here we present Kojak version 2.0, a major update to the original Kojak algorithm, which...
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) 
2023-01-18 | PXD037492 | Pride
Kojak Crosslinking mass spectrometry Proteomics Software tools Protein interaction Peptideprophet Xl-ms Trans-proteomic pipeline Computational proteomics Iprophet 
ProteomicsMag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
2025-07-02 | PXD042947 | panorama
ProteomicsRpomeroyi DSS-3 - Whole organism, NSAF (Krayushkinaetal,scidata2019)
abundance based on NSAF, Interaction consistency score: 10.0, Coverage: 45
ORGANISM(S): 246200 
2019-00-00 | 611508931 | PAXDB
ProteomicsRpomeroyi DSS-3 - Whole organism, SC (Krayushkinaetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 9.3, Coverage: 38
ORGANISM(S): 246200 
2019-00-00 | 402674203 | PAXDB
ProteomicsEvaluating the Performance of the Astral Mass Analyzer for Quantitative Proteomics Using Data Independent Acquisition
We evaluate the quantitative performance of the newly released Asymmetric Track Lossless (Astral) analyzer. Using data independent acquisition, the Orbitrap Astral mass spectrometer quantifies 5 times more peptides per unit time than state-of-the-art Orbitrap mass spectrometers, which have long been...
ORGANISM(S): Homo Sapiens 
2023-09-18 | PXD042704 | panorama
ProteomicsQuantification of Raloxifene Specific 471 Da Adducts in CYP3A4 and P450-Reductase
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit critical proteins, elicit immune responses, and cause life threatening adverse drug reactions. The masses of metabolites are frequently unknown, rendering traditional mass spectrometry-based proteomi...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-21 | PXD024932 | panorama
ProteomicsDetection and Quantification of Drug-Protein Adducts in Human Liver
Protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, toxicity and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due to lack of methods capable of discovering the proteins and peptides adducted by re...
ORGANISM(S): Homo Sapiens Spodoptera Frugiperda 
2024-10-25 | PXD054246 | panorama
Sort   by:  
 Page size