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ProteomicsMetabolism as an early predictor of DPSCs aging
Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration capabilities at the cellular level, but it is not clear if the different onset of stem cell aging betwee...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011962 | Pride
Aging stem cell 
ProteomicsAmino acid priming of mTOR is essential for heart regeneration
For a short period of time in mammalian neonates, the mammalian heart can regenerate via cardiomyocyte proliferation. This regenerative capacity is largely absent in adults. In other organisms, including zebrafish, damaged hearts can regenerate throughout their lifespans. Many studies have been perf...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-15 | PXD011791 | Pride
Heart regeneration Mtor 
ProteomicsFolliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
Using co-immunoprecipitation and mass spectrometry analysis we identify unique FLCN binding partners. The interactions of FLCN with components of the mTOR pathway (mTORC1 and mTORC2) reveal a mechanism of FLCN function during exit from naïve pluripotency.
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD011736 | Pride
Folliculin Mtor 
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016940 | Pride
Human Tmtpro Proteomics Sps-ms3 Cell lines 
ProteomicsBudding yeast relies on qualitative G1 cyclin specificity to couple cell cycle progression with morphogenetic development
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities associated with successive waves of G1, S and mitotic cyclins. Alternatively, the gradual quantitative rise of Cdk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022757 | Pride
Lc-ms/ms Tmt Cdk Yeast Cyclin Cell cycle Phosphoproteomics Cyclin-dependent kinase 
UnknownYB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.
Not available
S-EPMC4931992 | biostudies-literature
UnknownA Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.
Not available
S-EPMC6777093 | biostudies-literature
UnknownHepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.
Not available
S-EPMC4136616 | biostudies-literature
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016491 | Pride
Tmtpro16 
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014369 | Pride
Tmtpro16plex Real-time search Quantitative proteomics 
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