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ProteomicsCSR-1A post-translational modification
CSR-1 is an essential Argonaute protein that binds to a subclass of 22G-RNAs targeting most germline-expressed genes. Here we show that the two isoforms of CSR-1 have distinct expression patterns; CSR-1B is ubiquitously expressed throughout the germline and during all stages of development while CSR...
ORGANISM(S): Caenorhabditis elegans 
2021-06-17 | PXD021227 | Pride
C. elegans Dimethylation Csr-1a 
ProteomicsRG motifs promote piRNA-mediated gene silencing in C. elegans
Argonaute proteins are essential players in RNA silencing pathways, and their N-terminal extensions, particularly in the PIWI clade, often harbor conserved sequences like RG motifs. Despite their prevalence in Argonaute proteins, the role of these motifs remains poorly understood. In this study, we ...
ORGANISM(S): Caenorhabditis elegans 
2025-10-28 | PXD066798 | Pride
Prg-1 Tandem mass spectrometry C. elegans Immunoprecipitation Ip ms 
TranscriptomicsDistinct gene signatures define pathogen- versus diet-induced atherosclerosis development
The goal of this study was to define gene expression profiles in aortic tissue in response to three pro-atherogenic stimuli at two time points. We identified gene expression profiles induced by oral P.gingivalis (Pg), intranasal C. pneumoniae (Cp), and Western diet (WD) at acute (1 day after last in...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-60086 | biostudies-arrayexpress
UnknownThe Tasmanian devil microbiome-implications for conservation and management.
Not available
S-EPMC4687321 | biostudies-literature
ProteomicsBioID Assay of BirA*-hARGLU1 or BirA*-hGR in Flp-In T-Rex 293 cells
ARGLU1 is a Transcriptional Coactivator and Splicing Regulator Important for Stress Hormone Signaling and Development Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modu...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD012555 | Pride
Nr3c1 Splicing Gr Arglu1 
TranscriptomicsTracking Ebolavirus genomic drift with a resequencing microarray
This study evaluates a resequencing microarray designed to determine the sequence of the four major genes in the Ebolavirus genome, Nucleoprotein (NP), matrix protein (VP40), glycoprotein (GP) and polymerase (L). The array has the ability to determine the sequence of five species and strains: Zaire ...
ORGANISM(S): Tai Forest ebolavirus 
2021-01-29 | E-MTAB-10007 | biostudies-arrayexpress
TranscriptomicsDNA unmethylome profiling by covalent capture of CpG sites
Here we present an approach for the mapping of unmethylated DNA. Our technique is based on DNA methyltransferase-directed transfer of activated groups (mTAG) and covalent biotin tagging of unmodified CpG sites followed by affinity enrichment and interogation on tiling microarrays or next generation ...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-48994 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the brain response to cutaneous Aldara treatment
Analysis of whole mouse brain following peripheral, cutaneous immune stimulation with Aldara cream or aquaeous control cream. Results provide insight into the central response to peripheral inflammation Microarrays were used to investigate the global gene expression of mouse brains following periphe...
ORGANISM(S): Mus musculus 
2016-08-19 | E-GEOD-72214 | biostudies-arrayexpress
ProteomicsCellular determinants of targeted membrane protein degradation by lysosome targeting chimeras
Targeted protein degradation is a powerful therapeutic strategy that offers benefits over canonical target inhibition. Lysosome targeting chimeras (LYTACs) harness lysosome trafficking receptors such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) to direct secreted and membrane pro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037899 | Pride
Dia Lytac Quantitative proteomics Lysosome Crispri 
ProteomicsHEK293T cell degradome (pulse chase) time course (5h, 10, 15h) analysis upon Torin1 treatment. Related to Supplementary Table 3 from An et al (2020)
HEK293T Azidohomoalanine (AHA) Pulse Chase (degradome) time course experiment, were cells from various genetic background (WT, ATG7-/-, RB1CC1-/-) are treated or not with Torin1 for 5h, 10h or 15h. Samples are Biotin-click, and streptavidin enriched, digested and labeled with TMTpro 16plex.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-02 | MSV000091397 | MassIVE
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