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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
ProteomicsCul5 regulates CD4+ T cell fate choice and allergic inflammation
Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD028492 | Pride
Cis T-cell Asthma Allergy Cul5 Crl5 Cd4 Ubiquitin 
ProteomicsCul4b promotes CD4 T cell expansion by aiding the repair of damaged DNA
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. We have identified an E3 ubiquitin ligase, Cul4b, that regul...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD017699 | Pride
Dcaf1 Crl4 E3 ubiquitin ligase T cell receptor Apoptosis Smc1a Cul4b Cell cycle T cells Proliferation Adaptive immune response Dna damage response 
TranscriptomicsY. Sawada WT and pmg1pmg2
Comparing the gene expression patterns
ORGANISM(S): Arabidopsis thaliana 
2009-04-14 | E-MEXP-1578 | biostudies-arrayexpress
UnknownThe significance of T-BET-positive CD8 T-cells with diminished CD5 expression in Kikuchi-Fujimoto disease.
Not available
S-EPMC11528254 | biostudies-literature
MetabolomicsMetabolic consequences of cobalamin scarcity in diatoms as revealed through metabolomics (Thalassiosira pseudonana study)

Diatoms perform about 20% of photosynthesis on earth, play a crucial role in forming the base of the marine food web, and sequester anthropogenic carbon into the deep ocean through the biological pump. In some areas of the ocean, diatom growth is limited by the organic micronutrient cobalamin (vi...

2019-06-04 | MTBLS703 | MetaboLights
MetabolomicsDissolved organic matter produced by Thalassiosira pseudonana
Phytoplankton are significant producers of dissolved organic matter (DOM) in marine ecosystems but the identity and dynamics of this DOM remain poorly constrained. Knowledge on the identity and dynamics of DOM are crucial for understanding the molecular-level reactions at the base of the global carb...
2014-12-12 | MTBLS144 | MetaboLights
UnknownGenomic analysis of Agrobacterium radiobacter DSM 30147(T) and emended description of A. radiobacter (Beijerinck and van Delden 1902) Conn 1942 (Approved Lists 1980) emend. Sawada et al. 1993.
Not available
S-EPMC4149017 | biostudies-literature
UnknownSelective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers.
Not available
S-EPMC5815522 | biostudies-literature
UnknownImpaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination.
Not available
S-EPMC10154196 | biostudies-literature
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