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ProteomicsProteome expression profile of primary cilia deficient mIMCD3 cells
We characterized the protein expression profiles in ciliated kidney tubular epithelial cells and studied the changes upon loss of primary cilia.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD035290 | Pride
Cilia Autophagy Ripk3 Ciliopathies Nphp Kidney Necroptosis 
ProteomicsC. elegans wild type compared to vhl-1(ok161) RBPome and Proteome
We performed RNA interactome capture in wild type compared to vhl-1(ok161) loss-of-function worms. These data are combined with the proteome to distinguish changes in RBP abundance from differential binding events.
ORGANISM(S): Caenorhabditis elegans 
2020-01-08 | PXD014469 | Pride
Vhl-1 C. elegans Hif Hif-1 Rna-binding protein Rbp Hypoxia 
ProteomicsmIMCD RBPome and Proteome - We characterize the mRNA protein interactome of ciliated kidney tubular epithelial cells and we studied its modulation during hypoxia
We characterize the mRNA protein interactome of ciliated kidney tubular epithelial cells and we studied its modulation during hypoxia
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD010530 | Pride
Mrna interactome Mouse kidney tubuli cells 
ProteomicsAnalysis of the cilia membrane proteome by cmAPEX
APEX was targeted to the primary cilium of mouse IMCD cells using a 5HT6-APEX-GFP fusion construct. Proximity labling was performed using incubation with biotinphenol and H2O2. For details, please see the methods section of the accompanying paper.
ORGANISM(S): Mus musculus (Mouse) 
2017-07-18 | PXD005201 | Pride
Cilia Mouse Proteome Proximity labeling 
ProteomicsCharacterization of the interactomes of YAP and TAZ in podocytes identifies a relation between YAP and TAZ and proteins of the nuclear shuttling machinery
The two effector proteins of the Hippo signaling pathway, YAP and TAZ, play a pivotal role in the cellular homeostasis of podocytes and in the pathogenesis of focal segmental glomerulosclerosis (FSGS). We aim to unravel the unique and redundant functions of YAP and TAZ in the podocyte by identifying...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD040448 | Pride
Taz Podocyte Yap Hippo signaling Fsgs Yes-associated protein 1 Wwtr1 
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
ProteomicsResponse of podocytes to PAN - YAP-mediated mechanotransduction determines the podocyte's response to damage
Podocytes are terminally differentiated cells at the kidney filtration barrier and exposed to considerable mechanical strain. Podocyte injury causes morphological changes as a result of cytoskeletal reorganizations and failure of the filtration barrier. The transcriptional co-activators YAP/TAZ are ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-19 | PXD003872 | Pride
Human podocytes pan 
TranscriptomicsRNA-seq of wildtype and JADE1/2/3 knockout mIMCD3 kidney cells
JADE family proteins (JADE1/2/3) have been implicated in diverse cellular functions and signaling pathways ranging from WNT signaling and cell cycle control to cell death and complex transcriptional regulation through histone acetyl-transferase complexes. However, the function of the widely expresse...
ORGANISM(S): Mus musculus 
2022-12-31 | E-MTAB-11021 | biostudies-arrayexpress
ProteomicsHuman nucleolar RNA pol I interacting proteins identified by immuno-precipitation and mass spectrometry
Ribosome biogenesis is a highly regulated multistep process that controls cell growth and proliferation. The first and key regulatory step of ribosome biogenesis is represented by the transcription of ribosomal RNA (rRNA) genes by RNA polymerase (pol) I in the nucleolus. Activity of RNA pol I is tig...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD018143 | Pride
Human rnapoli interactors from nucleoli 
ProteomicsAATF interactome in human Kms27 cells
Multiple myeloma is a hematological neoplasm of plasma cells characterized by an abnormal production of immunoglobulins. Che-1/AATF (Che-1) is an RNA binding protein involved in transcription regulation and highly expressed in this malignancy. In order to better characterize its functions in this ty...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026659 | Pride
Multiple myeloma Aatf 
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