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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
ProteomicsGlucocorticoid treatment leads to aberrant ion and macromolecular transport mechanisms in regenerating zebrafish fins.
Bone is a highly regenerative tissue but it can be permanently lost due to severe trauma and as a result of disease. In zebrafish, which are capable of complex organ regeneration, intramembranous bones of the fins and skull regenerate rapidly even after profound loss. The fin regenerate, albeit bein...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-09-26 | PXD013552 | Pride
Prednisolone Glucocorticoid Fin regeneration Q exactive hf Lable free quantification Lfq Zebrafish 
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
ProteomicsProteomic characterization of CD34+ CD123+ stem cells from patients with acute myeloid leukemia
The comparative characterization of hematopoietic stem cells from healthy stem cell donors and patients with acute myeloid leukemia on a proteome level has the potential to reveal differentially regulated proteins which might be candidates for specific immunotherapy target molecules. Exemplarily, we...
ORGANISM(S): Homo sapiens (Human) 
2018-02-19 | PXD008378 | Pride
Proteomics Acute myeloid leukemia Lc-ms Aml 
ProteomicsSynergistic potential of sulfated hyaluronic acid and dexamethasone
Both sulfated hyaluronic acid and dexamethasone are candidates for the functionalization of bone grafts as they were shown to enhance the differentiation of osteoblasts from bone marrow stromal cells in vitro and in vivo. However, the underlying mechanisms are not fully understood. Furthermore, stud...
ORGANISM(S): Homo sapiens (Human) 
2019-03-15 | PXD009434 | Pride
Human Hbmsc Lc-msms Sulfated hyluronic acid Osteoblasts Dexamethasone 
ProteomicsQuantitative proteomics in osteoblasts-released matrix vesicles
The use of glycosaminoglycan-coated implants are a promising therapeutic approach in bone research since they mimic the native bone environment and facilitate the skeletonegenesis. Previous studies showed that sulfated glycosaminoglycans induce the osteoblastic phenotype, but the overall effect on t...
ORGANISM(S): Homo sapiens (Human) 
2015-11-30 | PXD002498 | Pride
Human Lc-msms Exosome Glycosaminoglycans Osteoblasts Silac Matrix vesicles 
TranscriptomicsMET after transient Twist activation results in de novo gain of malignant traits
During Epithelial-Mesenchymal Transition (EMT), apical-basal polarized epithelial cells are converted to front-to-back polarized mesenchymal cells that only form loose cell-cell adhesions. These phenotypic changes are accompanied by acquisition of increased motility and invasiveness. EMT programs ar...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-61206 | biostudies-arrayexpress
UnknownThe genomic and transcriptional landscape of primary central nervous system lymphoma.
Not available
S-EPMC9091224 | biostudies-literature
UnknownGenome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
Not available
S-EPMC6713272 | biostudies-literature
UnknownDissecting the genetic heterogeneity of gastric cancer.
Not available
S-EPMC10212786 | biostudies-literature
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