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ProteomicsMatrix-mediated activation of fibroblasts in rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting synovial joints and leading to cartilage damage and bone loss. This destruction is promoted by activated fibroblast-like synoviocytes (FLS) that show an invasive and migratory phenotype. The mechanisms of FLS activation are un...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-14 | PXD049800 | Pride
Chondrocytes Cytokines Fibroblast-like synoviocytes Extracellular matrix 
ProteomicsDEP-1 is a novel brain insulin receptor phosphatase and disallows the development of futile cycles
A healthy metabolism relies on the precise regulation of anabolic and catabolic pathways. Insulin and AMPK serve as key regulators of anabolism and catabolism, respectively. While insulin deficiency markedly impairs anabolism, insulin resistance in obesity leads to metabolic dysfunction especially v...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD051088 | Pride
Brain Insulin Dep-1 
ProteomicsCharacteristics of tendinopathy development in humans
Overuse injuries of tendon (tendinopathy) represents a significant musculoskeletal health problem, but its pathogenesis is only sparsely understood. We investigated the characteristics behind the development of tendinopathy in humans that had either early phase (1-2 months of symptoms, n=14) (ET) or...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD062414 | Pride
Ecm Clinical medicine Tendinopathy 
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
UnknownSUFU haploinsufficiency causes a recognisable neurodevelopmental phenotype at the mild end of the Joubert syndrome spectrum.
Not available
S-EPMC9411896 | biostudies-literature
UnknownThe Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against Herpes Zoster: Interim Results of an Extension Study of the Pivotal Phase 3 Clinical Trials ZOE-50 and ZOE-70.
Not available
S-EPMC9049256 | biostudies-literature
UnknownPrognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study.
Not available
S-EPMC11751936 | biostudies-literature
UnknownThe association between TMAO, CMPF, and clinical outcomes in advanced chronic kidney disease: results from the European QUALity (EQUAL) Study.
Not available
S-EPMC9761748 | biostudies-literature
UnknownAssociations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study.
Not available
S-EPMC8967670 | biostudies-literature
UnknownKidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD.
Not available
S-EPMC8259669 | biostudies-literature
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