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ProteomicsRescued ontogenesis in human DMD mini-muscles driven by tricyclo-DNA exon skipping-mediated dystrophin restoration
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by loss of function mutations in the dystrophin gene. There is currently no cure for DMD although various promising approaches are progressing through human clinical trials. Among them, exon-skipping therapy using antis...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD060394 | Pride
Dystophin 3d-cell culture Dmd 
ProteomicsSpatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaption at the muscle-tendon transition zone
Morphological studies of skeletal muscle tissue have provided detailed insights into the architecture of muscle fibers, the surrounding cells, and the extracellular matrix. However, a spatial proteomics analysis of the skeletal muscle, including the muscle-tendon transition zone, is lacking. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD046596 | Pride
Mtj Skeletal muscle Spatial proteomics 
ProteomicsEnlightening the decay: a combined experimental and computational analysis of mantATP turnover in skinned muscle fibers
Myosin is the primary motor protein in skeletal muscle, responsible for ATP hydrolysis that drives muscle contraction. In addition to force production, myosin consumes ATP during rest in futile cycles, a phenomenon associated with the Super Relaxed State (SRX), distinct from the disordered Relaxed S...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD060451 | Pride
Myh extraction Ghost fiber Single cell Muscle 
ProteomicsResting skeletal muscle reduces ATP turnover during hibernation
In mammals, loss of food intake and reduced mechanical loading/activity of skeletal muscles leads to a very rapid loss in mass and function. However, during hibernation in bears, despite spending months without feeding and with very modest muscle activity, only moderate muscle wasting is observed. P...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2024-12-06 | PXD050980 | Pride
Bear Hibernation Skinned muscle fibers Single muscle fiber 
ProteomicsMatrix-mediated activation of fibroblasts in rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting synovial joints and leading to cartilage damage and bone loss. This destruction is promoted by activated fibroblast-like synoviocytes (FLS) that show an invasive and migratory phenotype. The mechanisms of FLS activation are un...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-14 | PXD049800 | Pride
Chondrocytes Cytokines Fibroblast-like synoviocytes Extracellular matrix 
ProteomicsDEP-1 is a novel brain insulin receptor phosphatase and disallows the development of futile cycles
A healthy metabolism relies on the precise regulation of anabolic and catabolic pathways. Insulin and AMPK serve as key regulators of anabolism and catabolism, respectively. While insulin deficiency markedly impairs anabolism, insulin resistance in obesity leads to metabolic dysfunction especially v...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD051088 | Pride
Brain Insulin Dep-1 
ProteomicsCharacteristics of tendinopathy development in humans
Overuse injuries of tendon (tendinopathy) represents a significant musculoskeletal health problem, but its pathogenesis is only sparsely understood. We investigated the characteristics behind the development of tendinopathy in humans that had either early phase (1-2 months of symptoms, n=14) (ET) or...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD062414 | Pride
Ecm Clinical medicine Tendinopathy 
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
UnknownSUFU haploinsufficiency causes a recognisable neurodevelopmental phenotype at the mild end of the Joubert syndrome spectrum.
Not available
S-EPMC9411896 | biostudies-literature
UnknownThe Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against Herpes Zoster: Interim Results of an Extension Study of the Pivotal Phase 3 Clinical Trials ZOE-50 and ZOE-70.
Not available
S-EPMC9049256 | biostudies-literature
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