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MetabolomicsIndustrial by-products as a novel circular source of biocompatible extracellular vesicles

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. In this study we explore and define the use of food industry byproducts (BP) as a circular...

2022-05-17 | MTBLS2801 | MetaboLights
ProteomicsCharacterization of proteome dynamics in individual vascular layers at the early stage of acute sepsis
In this study we developed a stable isotope labeled of mammals (SILAM) model coupled to the application of differential systemic decellularization in vivo (DISDIVO) to evaluate the molecular dynamics of whole organism vascular beds at the initial phase of acute sepsis. Three different vascular layer...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-29 | PXD018274 | Pride
Lipopolysaccharide Endothelial dysfunction Disdivo. Endothelial cells Vascular beds 
ProteomicsProteomics of Hypothalamic Extracellular Vesicles at the Onset of Obesity
This proteomics dataset profiles hypothalamic extracellular vesicles (hEVs) during the early stages of diet-induced leptin resistance. Using next-generation proteomics in a discovery-driven approach, hEVs were analyzed from a hamster model subjected to a high-fat diet (HFD) for 30 days. The dataset ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2025-06-23 | PXD058280 | Pride
Obesity Extracellular vesicles Shotgun Hypothalamus 
ProteomicsCharacterization of Whole Blood EVs Using PRotein Organic Solvent PRecipitation
Blood plays a vital role in diagnostic medicine by providing essential information for assessing health and diagnosing various conditions. Routine blood tests can reveal important biomarkers that support early diagnosis and timely intervention. Recently, extracellular vesicles (EVs) have emerged as ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-25 | PXD066173 | Pride
Whole blood Human Extracellular vesicles Prospr 
ProteomicsProteomics characterization of extracellular vesicles derived from fermented food industry by-product: looking for new potential delivery vectors
In the last decade, the interest in extracellular vesicles (EVs) as safe and biocompatible nano-transporters has risen dramatically, as these nanoparticles can be used to increase the delivery efficiency rate and reduce secondary effects. However, the difficulty for its obtention in large quantities...
ORGANISM(S): Bos taurus (Bovine) 
2022-04-27 | PXD025780 | Pride
Food industry by-products Proteomics Evs Nanotransporters Nanovectors Molecular weight cut-off Lc-ms Extracellular vesicles Food-derived vesicles Circular economy 
MetabolomicsAROMA-GC: Green Automated Plasma Metabolome Profiling

Metabolomics enables the comprehensive profiling of low–molecular weight metabolites that reflect the interplay between environmental exposures and endogenous biological processes. As the downstream output of genomic, transcriptomic, proteomic, and epigenomic networks, the metabolome provides the...

2026-08-24 | MTBLS13319 | MetaboLights
ProteomicsShotgun mass spectrometry characterization of beef jerky and unprocessed beef meat
Snacking has been traditionally associated with consumption of carbohydrates- and fats-rich foods. Nevertheless, new dietary trends have modified the social perception and outcomes of this dietary habit promoting consumption of protein-rich foods. This study investigates the impact of food processin...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-23 | PXD012112 | Pride
Post-translational modifications Jerky Beef Processed foods Food technology 
MetabolomicsCharacterization of Whole Blood EVs Using PRotein Organic Solvent PRecipitation

Blood plays a vital role in diagnostic medicine by providing essential information for assessing health and diagnosing various conditions. Routine blood tests can reveal important biomarkers that support early diagnosis and timely intervention. Recently, extracellular vesicles (EVs) have emerged ...

2026-08-24 | MTBLS12801 | MetaboLights
ProteomicsTop-down characterization of lunasin in a commercial soybean-derived product
The presence of lunasin was investigated in two soybean products, raw soy seeds and a commercial soybean beverage powder. Lunasin from the commercial soybean derivative was purified by reverse phase high pressure liquid chromatography and bystrong anion exchange solid phase extraction. Lunasin was ...
ORGANISM(S): Glycine max 
2016-05-24 | PXD003064 | Pride
Glycation Proteomics Soybean Top-down Advanced glycation end produts 
ProteomicsPeptide recovery from acid-precipitated sodium deoxycholate pellet
Sodium deoxycholate (SDC) is MS-compatible ionic detergent which is compatible with in-solution tryptic digestion. SDC is removed from tryptic digested mixtures easily by acid precipitation and it has been demonstrated its capacity to increase trypsin activity. Additionally, and on the contrary to u...
ORGANISM(S): Homo sapiens (Human) 
2016-02-04 | PXD002811 | Pride
Human plasma / mass spectrometry / shotgun proteomics / sodium deoxycholate / trypsin digestion. 
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