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ProteomicsDifferential analysis of nucleolar proteomics in metastatic breast cancer
The nucleolus, responsible for ribosome biogenesis, acts as a key center for detecting and responding to cellular stress. Additionally, growing evidence suggests that ribosome biogenesis may play a significant role in promoting metastasis. A proteomic screen of nucleolar protein content between meta...
ORGANISM(S): Homo sapiens (Human) 
2025-07-27 | PXD060687 | Pride
Nucleolus Breast cancer Metastasis 
ProteomicsNovel binding partners of nucleolar HIF1A in hypoxic breast cancer cells
Solid tumors such as breast cancer have intratumoral regions of low oxygen tension, which influence a vast array of cellular responses. Hypoxia-Inducible Factor 1-alpha (HIF1α) represents the principal transcription factor orchestrating cellular responses to hypoxic conditions, mediating the regulat...
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD053134 | Pride
Breast cancer Nucleolus Hif1a Hypoxia 
ProteomicsIdentification of proteins bound with RPA194 at rRNA loci in primary versus metastatic breast cancer cells
The nucleolus, the site of ribosome biogenesis, serves as a central hub for sensing and responding to cellular stress and plays a crucial role in this process; furthermore, emerging evidence highlights the potential role of ribosome biogenesis in driving metastasis. A combined approach of chromatin ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-27 | PXD060651 | Pride
Breast cancer Rpa194 Chip Metastasis 
ProteomicsIdentification of proteins bound with RPA194 at rDNA loci post radiation in breast cancer cells
Following radiation damage, cells resume ribosome biogenesis for survival. We combined chromatin immunoprecipitation (ChIP) with mass spectrometry to identify key binding partners of RPA194 (the major subunit of RNA polI) at the rDNA loci in response to irradiation.
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041472 | Pride
Breast cancer Rdna Rpa194 Radiation Chip-ms Ir 
ProteomicsIdentification of proteins bound with RPA194 at rDNA loci in hypoxic breast cancer cells
We combined chromatin immunoprecipitation (ChIP) with mass spectrometry to identify key bidning partners of RPA194 (the major subunit of RNA polI) at the rDNA loci in breast cancer cells subjected to hypoxia.
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD053040 | Pride
Rpa194 Breast cancer Hypoxia Chip-ms 
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