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ProteomicsNuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell proliferation, but the role of GLS2 in cancer remains poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021033 | Pride
Gls2 
ProteomicsProteomics of the Bee brain and in olfactory memory
Previous work has shown that a series of honey bee brain proteins were probably linked to the proboscis extension reflex (PER) , a model studying insect behaviour. Herein, it was the aim of the study to generate a “synaptic proteome” and to investigate which proteins were paralleling olfactory cond...
ORGANISM(S): Apis mellifera (Honeybee) 
2019-05-27 | PXD011217 | Pride
Proboscis Bee Brain Olfactory memory 
ProteomicsProteomic studies on the swimbladder of the European eel (Anguilla anguilla)
The swimbladder of fish is a vital organ that along with gas glands in the swimbladder wall enables key physiological functions including buoyance, diving and coping with different hydrostatic pressures. Specific intramural glands provide gas for regulating gas pressure in the swimming bladder. Tran...
ORGANISM(S): Anguilla anguilla 
2018-02-27 | PXD007850 | Pride
Neurotransmitter Receptor Transporter Anguilla anguilla Swimbladder European eel 
ProteomicsUVA and to UV-oxidized lipids proteomic regulation of the human keratinocytes
Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators Ultraviolet A (UVA) would generate in primary human keratinocytes (KC). Mass spectrometric analysis of the oxidized phospholipidome of KC imm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-27 | PXD008050 | Pride
Uv Keratinocytes Oxidized lipids Human 
ProteomicsProteomics of rat overexpressing human DISC1 in the dorsal striatum
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat modestly overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-02-27 | PXD008123 | Pride
Synapse Disc1 Synaptosome Human 
ProteomicsSimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics
Large scale proteomic profiling of cell lines can yield valuable insights into the molecular signatures attributed to variable genotypes or induced perturbations. Specifically, the ability to perform deep and rapid proteome analysis of pharmacologically modulated cells could generate drug-protein as...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD031510 | Pride
Tmtpro Imids Celmods Targeted protein degradation Cancer cell lines Isobaric labeling 
ProteomicsSimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics
Large scale proteomic profiling of cell lines can yield valuable insights into the molecular signatures attributed to variable genotypes or induced perturbations. Specifically, the ability to perform deep and rapid proteome analysis of pharmacologically modulated cells could generate drug-protein as...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD034022 | Pride
Imids Tmtpro Celmods Targeted protein degradation Cancer cell lines Isobaric labeling 
ProteomicsAnalysis of pre-and postsynaptic brain receptors, transporters and channels by mass spectrometry
Although receptors, transporters and channels (RTCs) are key elements in the synaptic membrane, work on analysis and quantification of RTCs by mass spectrometry is limited. Additionally, there is not a single mass spectrometrical study that assigns the localisation of RTCs to the pre- or post-synap...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-12 | PXD001948 | Pride
Transporters and channels Presynaptic Receptors Postsynaptic Membrane 
ProteomicsA degron blocking strategy towards improved CRBN recruiting PROTAC selectivity
The different layers of complexity in PROTAC design have slowed the broad implementation of this novel pharmacological approach. Given the challenges and opportunities of CRL4CRBN hijacking PROTACs we set out to identify and develop broadly implementable strategies to generate PROTACs with improved ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD038298 | Pride
Lc-msms Human Protacs 
ProteomicsA degron blocking strategy towards improved CRBN recruiting PROTAC selectivity
The different layers of complexity in PROTAC design have slowed the broad implementation of this novel pharmacological approach. Given the challenges and opportunities of CRL4CRBN hijacking PROTACs we set out to identify and develop broadly implementable strategies to generate PROTACs with improved ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD038503 | Pride
Cereblon Protacs 
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