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ProteomicsInterfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins
Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically disordered protein α-synuclein is upregulated to high levels; and while toxic to dopaminergic neurons in Parkinson’s disease, it is highly beneficial for primary and metastatic me...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-07-03 | PXD030615 | Pride
Mhc Xenograft Melanoma Anle138b 
ProteomicsFAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
Type-I interferon (IFN-I) secretion provides a rapid host defense against infection with RNA-viruses. Upon entry into the host cell, the viral RNA triggers the activation of both RIG-I and TLR3 signaling pathways, ultimately leading to the production of type-I interferons. Since an exaggerated IFNa/...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD028918 | Pride
Fat10 Ubiquitin d Ubd Phosphorylation 
ProteomicsExtracellular vesicles derived from the choroid plexus trigger neural stem cells differentiation
An organized network of beating cilia transports cerebrospinal fluid (CSF) through the ventricles of the brain. CSF takes along diverse solutes including extracellular vesicles (EV), which arise from the choroid plexus, a secretory epithelium that reaches into the ventricles. Along their path throug...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-12-18 | PXD031862 | Pride
Cerebrospinal fluid Neural stem cells Mass spectrometry Extracellular vesicles Exosome assay Neural stem cell differentiation Choroid plexus derived vesicle 
ProteomicsLow-expressing synucleinopathy mouse models based on oligomer formation and C-terminal truncation of α-synuclein
Two mouse models were developed that expressed mutated human alpha synuclein under the control of endogenous murine αSyn (mαSyn) regulatory regions. The expression of the mαSyn was thereby abolished. The genetically ingeneered mice expressed either human αSyn (hαSyn) with a C-terminal deletion endin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-28 | PXD022314 | Pride
Α-synuclein mutants Neuroinflammation Transgenic mouse Truncation Motor impairment Oligomerization Parkinson’s disease Olfaction 
ProteomicsProtein phosphorylation in depolarized synaptosomes
Rat brain synaptosomes were used to study effects of calcium and synaptic vesicle cycling on protein phosphorylation following potassium chloride-induced depolarization.
ORGANISM(S): Homo sapiens (Human) Clostridium botulinum A str. Hall Rattus norvegicus (Rat) 
2021-02-17 | PXD020564 | Pride
Phosphorylation  synapse  synaptosomes  botulinum 
ProteomicsRegulated biogenesis and targeting of monotopic squalene monooxygenase requires the GET pathway
This study investigated get3 mutant yeast cell. Proteins of the GET pathway are involved in targeting of C-terminally anchored transmembrane proteins and protection against lipotoxicity. Get3 cells revealed an altered ergosterol production and susceptibility towards a sterol synthesis inhibiting dru...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-06-09 | PXD027705 | Pride
In-gel digestion Erg1 Terbinafine Lipotoxicity Lfq Squalene monooxygenase Get3 Get pathway 
ProteomicsCalcium-triggered (de)ubiquitination events in synapses
Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation cascades. However, little is known about other post-translational modifications, as ubiquitination. To address ...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2025-04-19 | PXD053470 | panorama
UnknownMetabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth Syndrome.
Not available
S-SCDT-10_15252-EMMM_202317399 | biostudies-other
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