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ProteomicsMultiplexed phosphoproteomics of low cell numbers using SPARCE
Understanding cellular diversity and disease mechanisms requires global analysis of proteins and their modifications. Ultrasensitive mass spectrometry-based proteomics enables unbiased protein-level analysis of low cell numbers, down to single cells. However, phosphoproteomics remains limited to hig...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD056902 | Pride
Tmt Glioblastoma Phospho Low-input 
ProteomicsKinase pathways in cilia disassembly signalling
Aim: To determine the major protein kinase pathways altered upon serum- or LPA-induced cilia disassembly Primary cilia are dynamic structures which must disassemble for a cell to go through mitosis and re-assemble in G0 to transduce essential signals. Also, in non-cycling cells (such as renal epithe...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD046462 | Pride
Cilia Lc-ms Lfq Phosphoproteomics 
ProteomicsIdentification of the protein interaction network of STAG2 protein isoforms with inclusion and exclusion of exon32
This study involves the identification of specific interactors for STAG2ex32+ and STAG2ex32delta. Plasmids expressing YFP-STAG2 isoforms were transfected into HCT116OsTIR cells using untransfected cells as mock control. 40h post transfection, whole cell lysates were extracted and STAG2 isoforms were...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD041975 | Pride
Ap-ms 
ProteomicsIdentification of the protein interaction network of Stag proteins
This study involves the identification of specific Stag1 interactors with and without Cohesin loss. Stag1 was immunoprecipiated from human HCT116 cells, under 4 treatments - untreated (UTR), Non-specific siRNA treatment (SiCON), SA1 siRNA treatment (SiSA1) and Auxin treatment for Cohesin loss (IAA)....
ORGANISM(S): Homo sapiens (Human) 
2023-04-18 | PXD024354 | Pride
Human Ap-ms Lc-ms Lfq Stag 
ProteomicsComprehensive understanding the molecular components of LTBR signalling complex in cancers
Lymphotoxin beta receptor (LTBR), a member of TNFRSF, was identified as a key regulator in the development, organization, and homeostasis of lymphoid tissues (Wolf, Seleznik, Zeller, & Heikenwalder, 2010). Recently, LTBR has been shown to play a role in tumor biology, both in solid tumors and in hem...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD034142 | Pride
Human Ap-ms Lc-ms Lfq 
ProteomicsNascent RNA antagonises the interaction of regulatory proteins with chromatin
Using label-free quantification to identify the changes in the association of proteins with chromatin upon RNA degradation in cells with RNaseA.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-25 | PXD018641 | Pride
Mouse chromatin chromatome lc-msms 
ProteomicsIdentification of changes in posttranslational modifications of EGFR and in EGFR-binding partners in head and neck cancer cells upon treatment with EGF or the EGFR antibody mixture Sym004
This study aimed at determining the proteins that interact with EGFR and the changes in post-translational modifications within them.
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016208 | Pride
Human Egfr Lc-ms/ms 
ProteomicsAnalysis of RIPK1 phosphorylation in vitro
This study aims at determining which RIPK1 residues are phosphorylated.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD008518 | Pride
Ms Phosphorylation Ripk1 
ProteomicsAnalysis of the TNFR1-SC from HOIP-proficient and -deficient A549 cells
This study aimed at determining which components of the TNFR1-SC are recruited in dependency of HOIP.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD008497 | Pride
Ap-ms Tnfr1-sc Hoip 
ProteomicsAnalysis of the TBK1 interactors from TBK1-deficient A549 cells reconstituted with moTAP TBK1 or empty vector
This study aimed at determining the proteins that interact with TBK1.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD010777 | Pride
A549 Tbk1 
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