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ProteomicsSynthetic (Phospho)Peptide Library
The submitted dataset contains raw files from 96 synthetic peptide libraries, using either HCD or ETD as fragmentation technique. The synthesized 96 tryptic peptide libraries containing >100,000 unmodified peptides plus their corresponding >100,000 phosphorylated counterparts with precisely known s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-14 | MSV000091718 | MassIVE
ProteomicsSimulated spectral library searching on TripleTOF phosphopeptide datasets
Synthetic phosphopeptides and enriched K562 cell phosphopeptides were analyzed using a TripleTOF 6600 mass spectrometer before and after enzymatic dephosphorylation. Dephosphorylated peptides identified by X!Tandem database searching were subjected to spectral simulation of all possible single phosp...
ORGANISM(S): Homo Sapiens (human) 
2019-12-03 | PXD012433 | JPOST Repository
ProteomicsEncoding the human serine phosphoproteome in an engineered bacterial system
We synthesize a synthetic representation of the human serine phosphoproteome, expressed heterologously as >=31 amino acid phosphopeptides in an engineered strain of E. coli. We confirm that tens of thousands of these phosphopeptides can be successfully expressed and retain important functional chara...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-04-17 | PXD008707 | Pride
Phosphorylation Phosphoproteomics Lc-msms 
UnknownModification of Luffa Sponge for Enrichment of Phosphopeptides.
Not available
S-EPMC6982136 | biostudies-literature
ProteomicsSynthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancer
PTEN is a tumor suppressor that is often inactivated in cancer and possesses both lipid and protein phosphatase activities. We report the metabolic regulator PDHK1 (pyruvate dehydrogenase kinase1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells. The predominant mechanism of P...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD014707 | Pride
Metabolism Cancer Protein phosphatase Pten Pdhk1 Nfkb Nkap Synthetic lethality Signaling 
ProteomicsCancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC
The FBXW7 tumour suppressor is commonly mutated, deleted or hypermethylated in a variety of cancer histologies. The tumour suppressive role of the FBXW7 protein has been ascribed to its ability to drive the ubiquitination and degradation of oncoproteins via its role as a substrate recognition subuni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043904 | Pride
Cdc Fbxw7 Synthetic lethal 
ProteomicsSpecter - Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics
These data cover all of the analyses described in the paper "Specter: linear deconvolution as a new paradigm for targeted analysis of data-independent acquisition mass spectrometry proteomics". Specifically, the data consist of - 20 DIA and DDA files from the HEK293T/synthetic phosphopeptides spike-...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-03-19 | PXD006722 | Pride
Proteomics Data-independent acquisition 
ProteomicsInference and quantification of peptidoforms in large sample cohorts by SWATH-MS: PTM-SWATH-MS Gold Standard data set
The PTM-SWATH MS Gold Standard data set consists of a previously published (Soste et al., 2014, PMID:25194849) set of 579 unpurified, synthetic, heavy-isotope labeled phosphopeptides (Thermo Scientific Biopolymers). These phosphopeptides represent biologically relevant sequences from S. cerevisiae p...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2017-06-12 | PXD004573 | Pride
Ipf Openswath Synthetic phosphopeptides Gold standard data set Human Yeast 
UnknownColander: a probability-based support vector machine algorithm for automatic screening for CID spectra of phosphopeptides prior to database search.
Not available
S-EPMC2587238 | biostudies-literature
ProteomicsComprehensive spectral library from the pathogenic bacterium Streptococcus pneumoniae with focus on phosphoproteins
In this study, a comprehensive spectral library for S. pneumoniae with an emphasis on phosphopeptide spectra was compiled. In total, 76% of the theoretical S. pneumoniae proteins were stored in a spectral library. Additionally, in combination with classical database search algorithms and the spectra...
ORGANISM(S): Streptococcus Pneumoniae D39 
MSV000084269 | MassIVE
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