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ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
TranscriptomicsTranscription profiling of human skeletal muscle from Hiv-Infected Men experiencing weight loss treated with testosterone
Context: Although androgen treatment increases muscle mass in HIV-infected men, the underlying mechanisms are poorly understood. Analysis of genome-wide microarray data obtained from skeletal muscle biopsies can be used to profile androgen-regulated pathways. Objective: To identify genes and pathway...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-5106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat gastrocnemius muscles from male animals to assess the effects of testosterone on dexamethasone-induced changes in gene expression
Glucocorticoids are a well recognized and common cause of muscle atrophy. Glucocorticoid-induced atrophy can be prevented by testosterone, but the molecular mechanisms underlying such protection have not been described. Thus, the global effects of testosterone on dexamethasone-induced changes in ge...
ORGANISM(S): Rattus norvegicus 
2009-07-11 | E-GEOD-12296 | biostudies-arrayexpress
MetabolomicsIntegrated Metabolomics and Transcriptomics Analyses Reveal Anthocyanin and Carotenoid Biosynthesis Involved in Color Development in Willow Bark

Shrub willow has strong adaptability, large biomass and short rotation period. Colorful willow barks have great ornamental and economic value. To study the color regulation mechanism, metabolomics and transcriptomics were used to analyze the purple, green and red barks. In the positive mode, a to...

2022-08-10 | MTBLS4820 | MetaboLights
TranscriptomicsLeptin dependent control of testosterone regulated hepatic lipid metabolism
Population based studies have established that androgen deficiency in males correlates with type 2 diabetes, visceral adiposity, and metabolic syndrome. Androgen therapy has been investigated as a possible treatment regime to combat these disorders. However, the molecular mechanism of androgen effec...
ORGANISM(S): Rattus norvegicus 
2012-09-02 | E-GEOD-23941 | biostudies-arrayexpress
MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_Mycelium

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14012 | MetaboLights
TranscriptomicsTranscription profiling by array of wound samples from rats treated with the 5alpha-reductase inhibitor MK-434
The present study aimed to delineate the central mechanisms by which androgens delay wound repair. Blocking the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) by 5alpha-reductase limits its ability to impair skin wound healing, suggesting that DHT is a more potent inhibitor of repair...
ORGANISM(S): Rattus norvegicus 
2009-02-20 | E-MEXP-1232 | biostudies-arrayexpress
TranscriptomicsEffect of AMPK activation by AICAR on MA-10 Leydig cell transcriptome
Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by LH via its receptor leading to increased cAMP production and expression of the ster...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50118 | biostudies-arrayexpress
TranscriptomicsTestosterone differentially affects expression in the hypothalamus and the ventromedial telencephalon (VmT) of Juncos
Despite sharing much of their genomes, males and females are often highly dimorphic, reflecting at least in part the resolution of sexual conflict in response to sexually antagonistic selection. Sexual dimorphism arises owing to sex differences in gene expression, and steroid hormones are often invo...
ORGANISM(S): Junco hyemalis 
2013-01-30 | E-GEOD-41076 | biostudies-arrayexpress
UnknownCrucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone.
Not available
S-EPMC4369260 | biostudies-literature
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