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TMT isotopic labelling to relative Quantitation of proteins from THP1 Macrophage EVs after C.albicans interaction.
ORGANISM(S): Bos taurus (Bovine) Candida albicans (Yeast) Homo sapiens (Human) 
2022-02-28 | PXD004517 | Pride
Vero cells were infected with Zika virus in three biological replicates and sampled at three post-infection timepoints (12 hrs, 24 hrs, 48 hrs). Biological replicate mock uninfected cells were also done for each timepoint. We used TMT6 labeled quantitation at each timepoint to examine proteome chang...
ORGANISM(S): Zika Virus (ncbitaxon:64320) Homo Sapiens (ncbitaxon:9606) 
2020-03-05 | MSV000085057 | MassIVE
SUMMARY Congenital muscular dystrophy with laminin á2 chain-deficiency (MDC1A) is one of the most severe forms of muscular disease and is characterized by decreased muscle tone at birth, reduced movements and contractures. The genetic basis of MDC1A is well-known, yet the secondary mechanisms ultima...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-08 | PXD000978 | Pride
Proteomic strategy to define therapeutically relevant targets in cell lines that contain the 11q13 amplicon compared to those that do not and to ascertain which genes are amplified at the protein level and, concomitantly, are key drivers for tumor growth and/or maintenance. Furthermore, so called p...
ORGANISM(S): Homo sapiens (Human) 
2015-08-04 | PXD002486 | Pride
Files associated with "A Bioconductor workflow for processing, evaluating and interpreting expression proteomics data".
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD041794 | Pride
Ubiquitination/deubiquitination belong to the most important regulatory mechanisms carried out through the attachment/removal of the ubiquitin molecule, respectively. The process is necessary not only to mark molecules for degradation, but also for example to the activation of signaling pathways lea...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043492 | Pride
In this project, a more efficient methodology for obtaining multi-timepoint kinetic data for proteome-wide analyses of protein turnover is developed and used to globally measure the kinetics of protein turnover in primary human fibroblasts (HCA2-hTert). This approach takes advantage of the multiplex...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD004725 | Pride
Cognitive impairment due to cancer and its therapy is a major concern among cancer survivors. Extracellular vesicles (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially impacting the cognitive abilities of cancer survivors. We i...
ORGANISM(S): Homo sapiens (Human) 
2021-05-27 | PXD021395 | Pride
The PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2-phosphatase, PTEN. Despite huge investment, the drivers of the PI3K network in normal tissues and how they adapt to overactivation are unclear. We find that in hea...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-23 | PXD043239 | Pride
ClpP is important for bacterial growth and plays an indispensable role in cellular protein quality control systems by refolding or degrading damaged proteins, but the role of ClpP on Enterococcus faecalis is still obscure. A clpP deletion mutant (△clpP) was constructed in E. faecalis strain OG1RF in...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2020-03-06 | PXD014211 | Pride
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