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ProteomicsLysosomal proteome characterization during TRPML1 activation by MLSA5 in human cancer cells
To capture the changes in the lysosomal proteome upon TRPML1 activation, achieved using a small molecule agonist MLSA5, human cancer cells, with or without gene-editing, stably expressing TMEM192-mRFP-3xHA (Lyso-IP), were treated with MLSA5 and Lyso-IP samples were prepared and processed for TMT-MS ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD054968 | Pride
Mlsa5 Tmt A101d V-atpase Lysosome Trpml1 Dmxl2 Dmxl1 Lyso-ip U2os Atg16l1 
ProteomicsEndolysosomal TRPML1 channel regulates cancer cell-migration by facilitating the intracellular trafficking of E-cadherin and β1-integrin
Recently, endolysosomal cation channels have emerged as an attractive anti-cancer target: namely the mucolipin subfamily of transient potential receptors (TRPMLs), which comprises three isoforms – TRPML1 (MCOLN1), TRPML2 (MCOLN2), and TRPML3 (MCOLN3). TRPML1, the most intensively researched member o...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-20 | PXD046212 | Pride
Cancer biology Lysosome Adhesion Ion channel Migration 
UnknownTRPML1 gating modulation by allosteric mutations and lipids.
Not available
S-EPMC11245044 | biostudies-literature
UnknownTRPML1 gating modulation by allosteric mutations and lipids.
Not available
S-EPMC11473102 | biostudies-literature
UnknownLysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
Not available
S-EPMC8977057 | biostudies-literature
UnknownHRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
Not available
S-EPMC6446245 | biostudies-literature
UnknownCellular zinc levels are modulated by TRPML1-TMEM163 interaction.
Not available
S-EPMC4205267 | biostudies-literature
UnknownActivating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.
Not available
S-EPMC2797275 | biostudies-literature
UnknownLAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibition.
Not available
S-EPMC11621854 | biostudies-literature
UnknownAtomic insights into ML-SI3 mediated human TRPML1 inhibition.
Not available
S-EPMC8570993 | biostudies-literature
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