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ProteomicsThe type VII secretion system protects Staphylococcus aureus against host-specific fatty acids
The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that are pivotal for bacterial virulence. The mechanisms underlying T7SS-mediated staphylococcal survival during infection are nevertheless unclear. Here we show that EsxC, a small secreted effector implicated in bac...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD013081 | Pride
Type vii secretion system Staphylococcus aureus Long-chain unsaturated free fatty acids 
ProteomicsSecretomics of the Staphylococcus aureus Type VII protein secretion system
The type VII protein secretion system (T7SS) is conserved across Staphylococcus aureus strains and plays important roles in virulence and interbacterial competition. To date only one T7SS substrate protein, encoded in a subset of strains, has been functionally characterized. Here, using an unbiased ...
ORGANISM(S): Staphylococcus aureus 
2020-09-28 | PXD011358 | Pride
Secretion T7ss Staphylococcus aureus Secretome 
ProteomicsThe ESX-4 type VII secretion system in required for efficient heme utilization by Mycobacterium tuberculosis
In this study our primary objective was to identify unknown components that are required of Mtb Hm acquisition. Herein, we show that the ancestral ESX-4 type VII secretion system (T7SS) which was thought to be inactive in Mtb is required for efficient Hm utilization. We also identified that the cult...
ORGANISM(S): Acyrthosiphon pisum (Pea aphid) 
2023-01-31 | PXD036081 | Pride
Type vii secretion Iron acquisition Mycobacterium tuberculosis Heme Channel protein Ppe Outer membrane Esx-4 
ProteomicsProteolytic-independent role of mycosins in stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes.
Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5, which have central roles in virulence and viability. One of the conserved components of these systems, the serine protease mycosin (MycP), has been shown to be essential for secretion by ESX-1 and ESX-5. How...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2016-10-11 | PXD003766 | Pride
Mycobacterium marinum Tuberculosis Esx1 Single-shot Esx5 Label-free T7s 
UnknownArchitecture of the mycobacterial type VII secretion system.
Not available
S-EPMC6914368 | biostudies-literature
UnknownBacterial secretion chaperones: the mycobacterial type VII case.
Not available
S-EPMC6109436 | biostudies-literature
ProteomicsThe staphylococcal type VII secretion system impacts daptomycin sensitivity through controlling bacterial cell surface integrity
The human pathogen Staphylococcus aureus encodes a specialised type VII secretion system (T7SS), which plays an important role in bacterial virulence during infection. However, the functions the T7SS during infection and in bacterial physiology remain unclear. Here we demonstrate that S. aureus stra...
ORGANISM(S): Staphylococcus aureus 
2024-04-19 | PXD047096 | Pride
Cell membrane integrity Daptomycin Warwick_rtp Type vii secretion system Intracellular infection Membrane fluidity 
TranscriptomicsDual RNA-seq of THP-1 macrophages infected with JE2 WT and ΔessC at 2 and 6 hours post infection
This experiment was conducted to uncover global transcription differences caused by Staphylococcal T7SS during early and mid-late macrophage infection.
ORGANISM(S): mixed sample 
2026-01-01 | E-MTAB-16250 | biostudies-arrayexpress
ProteomicsSecretion profling of Mycobacterium xenopi ESX-5 mutants
The ESX-5 system from Mycobacterium xenopi was expressed in Mycobacterium smegmatis on a constituatively expressed plasmid. This expression plasmid, pMX-Mxen-ESX-5 enocodes the seceretion complex and 3 secreted substrate pairs : EsxM+EsxN; PE19.1+PPE26.1 ; and PE19.2+PPE26.2. Several mutants in the ...
ORGANISM(S): Mycobacterium xenopi RIVM700367 Bacteria 
2026-07-07 | PXD048552 | Pride
Type vii secretion Mycobacteria 
UnknownMycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion.
Not available
S-EPMC8092274 | biostudies-literature
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