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TranscriptomicsDual RNA-seq of THP-1 macrophages infected with JE2 WT and ΔessC at 2 and 6 hours post infection
This experiment was conducted to uncover global transcription differences caused by Staphylococcal T7SS during early and mid-late macrophage infection.
ORGANISM(S): mixed sample 
2026-01-01 | E-MTAB-16250 | biostudies-arrayexpress
UnknownCrosstalk between the ancestral type VII secretion system ESX-4 and other T7SS in Mycobacterium marinum.
Not available
S-EPMC8718981 | biostudies-literature
UnknownLXG Toxins of Bacillus Velezensis Mediate Contact-Dependent Inhibition in a T7SS-Dependent Manner to Enhance Rhizosphere Adaptability.
Not available
S-EPMC11942605 | biostudies-literature
ProteomicsSecretomics of the Staphylococcus aureus Type VII protein secretion system
The type VII protein secretion system (T7SS) is conserved across Staphylococcus aureus strains and plays important roles in virulence and interbacterial competition. To date only one T7SS substrate protein, encoded in a subset of strains, has been functionally characterized. Here, using an unbiased ...
ORGANISM(S): Staphylococcus aureus 
2020-09-28 | PXD011358 | Pride
Secretion T7ss Staphylococcus aureus Secretome 
UnknownGenomics of Atlantic Forest Mycobacteriaceae strains unravels a mobilome diversity with a novel integrative conjugative element and plasmids harbouring T7SS.
Not available
S-EPMC7478629 | biostudies-literature
UnknownA toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria.
Not available
S-EPMC9616950 | biostudies-literature
UnknownCrystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
Not available
S-EPMC4741195 | biostudies-literature
ProteomicsThe staphylococcal type VII secretion system impacts daptomycin sensitivity through controlling bacterial cell surface integrity
The human pathogen Staphylococcus aureus encodes a specialised type VII secretion system (T7SS), which plays an important role in bacterial virulence during infection. However, the functions the T7SS during infection and in bacterial physiology remain unclear. Here we demonstrate that S. aureus stra...
ORGANISM(S): Staphylococcus aureus 
2024-04-19 | PXD047096 | Pride
Cell membrane integrity Daptomycin Warwick_rtp Type vii secretion system Intracellular infection Membrane fluidity 
ProteomicsThe type VII secretion system protects Staphylococcus aureus against host-specific fatty acids
The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that are pivotal for bacterial virulence. The mechanisms underlying T7SS-mediated staphylococcal survival during infection are nevertheless unclear. Here we show that EsxC, a small secreted effector implicated in bac...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD013081 | Pride
Type vii secretion system Staphylococcus aureus Long-chain unsaturated free fatty acids 
ProteomicsImmunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I (DDA data)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a leading cause of infectious disease mortality worldwide for which no sufficiently protective vaccine exists. CD8+ T cells contribute to protective immunity to TB, but the antigenic targets presented on MHC-I by macrophages infected ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Homo sapiens (Human) 
2023-04-24 | PXD037837 | Pride
Macrophage Human Tuberculosis Vaccines Infectious disease Immunopeptidomics Phagocyte Immunopeptidome Mhc-i Tb 
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