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Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
ProteomicsMolecular basis of USP7 inhibition by selective small molecule inhibitors
Modification by ubiquitin controls the stability of most cellular proteins, and deregulation contributes to a variety of human diseases such as cancer. Deubiquitinases (DUBs) remove ubiquitin from proteins, and the inhibition of DUBs has been recognized as a therapeutic strategy to induce degradatio...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD006418 | Pride
Usp7 inhibitors cancer 
GenomicsUSP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesis
USP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesis
PRJNA1200707 | ENA
ProteomicsUSP7 substrates identified by proteomics analysis reveal the specificity of USP7 and its inhibitors
Deubiquitylating enzymes (DUBs) remove ubiquitin chains from proteins and regulate protein stability and function. USP7 is one of the most compressively studied DUBs. Since USP7 has several well-known substrates important for cancer progression, such as MDM2, N-MYC and PTEN, USP7 becomes a promising...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-04 | MSV000087940 | MassIVE
ProteomicsWhole proteome measurement to determine effects of USP7 targeting small molecules in pancreatic cancer cells (Panc89) and melanoma cells (MaMel47)
Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared U...
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD070431 | Pride
Mamel47 Panc89 Lc-ms Usp7-targeting degrader Protac 
ProteomicsDeep quantitative proteomics of TNBC and SUM149 cell lines treated with USP7 inhibitors
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059902 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
UnknownUSP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective.
Not available
S-EPMC9688046 | biostudies-literature
TranscriptomicsUSP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesis
Epstein-Barr virus (EBV) is a ubiquitous human ɣ-herpesvirus implicated in various malignancies, including Burkitt’s lymphoma and gastric carcinomas. In most EBV-associated cancers, the viral genome is maintained as an extrachromosomal episome by the EBV nuclear antigen-1 (EBNA1). EBNA1 is considere...
ORGANISM(S): Homo sapiens 
2025-01-31 | GSE284839 | GEO
ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
UnknownSelective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Not available
S-EPMC4025646 | biostudies-literature
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