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ProteomicsCardiac myofilament isoforms - Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches
Purpose: The identification of protein isoforms in complex biological samples is challenging. We, therefore, used a mass spectrometry (MS) approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a partic...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-08-28 | PXD000874 | Pride
Multiple search engines Bioinformatics Cardiomyocyte Sarcomere Protein isoforms Rat cardiac tissue Myofilament proteome Protein sub-isoforms Lc-ms/ms 
ProteomicsHyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy
Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca2+-sensitivity and mechanosensing. Treatment with cardiosphere-derived cells (CDC...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-04-23 | PXD025555 | Pride
Heart failure with preserved ejection fraction (hfpef)  diastolic dysfunction  myofilament phosphorylation Protein kinase c (pkc) Cardiosphere-derived cell (cdc) 
ProteomicsMolecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability
Priapism is a disorder in which prolonged penile erection persists uncontrollably, potentially leading to tissue damage. Priapism commonly afflicts patient populations with severely low nitric oxide (NO) bioavailability. As NO is a primary mediator of erection, the molecular mechanisms involved in p...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-13 | PXD007713 | Pride
Priapism Proteomics Nitric oxide Erectile Mass spectrometry Penis Pka Gpcr 
ProteomicsProtein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1, part 2
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that enable cells to adapt to reduced O2 availability. HIF-1 controls physiological processes that are dysregulated in cancer and heart disease, including angiogenesis, energy metabolism, and immunity. These di...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-06-07 | PXD003795 | Pride
Camp Hif Hypoxia Cancer cell Cardiomyocyte Pka Phosphorylation 
ProteomicsComparative proteomic analysis of HPV(+) oropharyngeal squamous cell carcinoma recurrence
The global rise of HPV(+) oropharyngeal squamous cell carcinoma (OPSCC) has generated considerable interest underlying its etiology and management. Despite an overall decline in head and neck malignancies, the incidence in OPSCC has by contrast sharply risen, with HPV(+) subtypes now comprising 80% ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-05 | PXD028618 | Pride
Head and neck cancer Ffpe Carcinoma Ihc Hpv 
ProteomicsVinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Rat Data
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. Here we present the proteomes...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-15 | PXD001839 | Pride
Proteomics Rattus norvegicus Mass spectrometry Cytoskeleton Macacca mulatta Biomarkers Stiffness Drosophila melanogaster 
ProteomicsVinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Monkey data
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. Here we present the proteomes...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2018-10-19 | PXD001842 | Pride
Proteomics Rattus norvegicus Mass spectrometry Cytoskeleton Macacca mulatta Biomarkers Stiffness Drosophila melanogaster 
ProteomicsHs_Normal_Retina
The proteome of normal human retina
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005190 | PeptideAtlas
ProteomicsPINE: An Automation Tool to Extract & Visualize Functionally Enriched Networks from Mass Spectrometry-Based Proteomics Datasets
Recent surges in mass spectrometry-based proteomics studies demands a concurrent rise in speedy and optimized data processing tools and pipelines. While several stand-alone databases exist that store gene interaction and annotation information, we developed Protein Interaction Network Extractor (PIN...
ORGANISM(S): Mus Musculus 
2021-02-23 | PXD017324 | panorama
ProteomicsOncometabolism Drives Autophagy Activation in Skeletal Muscle
Metabolic rewiring is a well-established feature of muscle cells and a hallmark of cancer. In isocitrate dehydrogenase 1 and 2 mutant tumors, increased production of the oncometabolite D-2-hydroxyglutarate (D2-HG) is associated with myopathy. The connection between metabolic changes and proteomic re...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD022137 | Pride
Autophagy Mouse Cancer Cachexia D2-hg Skeletal muscle 
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