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ProteomicsAssessment of protein extraction and digestion efficiency of well-established shotgun protocols for heart proteomics
In this study, we evaluated three well-established sample preparation methods for shotgun proteomics, named: i) UREA; ii) sodium dodecyl sulfate (SDS); and iii) filter-aided sample preparation (FASP) protocols. We focused our analysis on protein extraction and digestion from heart left ventricle (LV...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-05-21 | PXD012591 | Pride
Lc-msms Rat Dimethyl labeling Heart Fasp 
ProteomicsMolecular mechanisms underlying the antitumoral effects of Angiotensin-(1-7) in the A549 cell line
Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide of the renin-angiotensin system (RAS) with antitumoral effects reported in various tumoral cell lines, including the lung adenocarcinoma A549. While previous studies have shown that Ang-(1-7) modulates MAPK and PI3K-AKT signaling, the precise molecular...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD066687 | Pride
A549 cell line Renin-angiotensin system Angiotensin-(1-7) 
ProteomicsShedding lights on the alamandine signaling in CHO-MrgD and human pancreatic carcinoma cells: an antiproliferative effect was unveiled
Antiproliferative effect of ang-(1-7) has been further described and detailed, assessing its possibility as a therapeutic cancer control agent. Other endogenous peptides in this system have been studied and characterized, such as alamandine, a heptapeptide very similar to ang-(1-7) in terms of amino...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2022-06-07 | PXD018529 | Pride
Mia paca-2 Human Cho Alamandine treatment 
ProteomicsProteomic study of triple negative breast cancer cell lines at different tumorigenic stages reveals a divergent reprogramming metabolism
Breast cancer is the leading type of cancer. The triple negative is the most aggressive type of breast cancer, as it is resistant to several treatments as hormone based, for example. Cell metabolism is altered in cancer cells as they favor anaerobic pathways to produce energy in a faster pace and in...
ORGANISM(S): Homo sapiens (Human) 
2022-06-07 | PXD028400 | Pride
Tmt Proteomics Breast cancer 
ProteomicsIsoproterenol-induced cardiac hypertrophy trigger proteome remodeling of mouse cardiomyocytes
Cardiac hypertrophy consists in the enlargement of cardiomyocytes and alteration of the extracellular matrix organization in response to physiological or pathological stress. In pathological hypertrophy ocuurs myocardial damage, loss of cardiomyocytes, fibrosis, inflammation, sarcomere disorganizati...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD013020 | Pride
Hypertrophy Heart Mouse Isoproterenol 
ProteomicsPhosphoproteomics of mouse cardiomyocytes reveals signalling pathways triggered by a vasodilator cryptide
Animal venoms are natural sources of bioactive molecules such as cryptides that consist in biological active peptides released after proteolytic cleavage of a peptide or protein precursor. The KPP is a cryptided derived from the c-terminal of an hypotensin (TsHpI) a peptide isolated from the venom o...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD015068 | Pride
Hipotensins Venome Scorpion Cryptide Cardiomyocytes Phosphopreteomics 
ProteomicsThe role of vagus nerve in liver physiology
Liver metabolism is highly dynamic and is regulated by nutrient availability and humoral factors. A growing body of evidence suggests that the autonomous central nervous system also plays an important role in coordinating hepatic metabolic functions, which confer the flexibility needed for adaptatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD041052 | Pride
Liver Proteome Vagus nerve 
ProteomicsSurviving Mars: The role of black fungus Rhinocladiella similis in understanding life in perchlorate-rich environments
The study of the survival of terrestrial microorganisms in Martian conditions, especially in the presence of perchlorates, offers crucial insights for astrobiology. This research investigates the resilience of the extremophilic black fungus Rhinocladiella similis to the exposure to magnesium perchlo...
ORGANISM(S): Rhinocladiella similis 
2025-05-26 | PXD050600 | Pride
Omics. Space exploration Uv-c radiation Rhinocladiela similis Extremophiles Perchlorate brines 
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