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ProteomicsTitration of Sall4 by the NuRD complex facilitates neural differentiation of ES cells
Sall4 is a transcription factor essential for early mammalian development. Though it is reported to play an important role in embryonic stem (ES) cell self-renewal, whether it is an essential pluripotency factor has been disputed. Though Sall4 is known to associate with the Nucleosome Remodeling and...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-02 | PXD003614 | Pride
Ap-ms of flag-tagged sall4 in mouse embryonic stem cells 
ProteomicsFunctional analysis of somatic variants found in endometrial tumor-specific ER-alpha enhancers
Biological implications of healthy- and tumor-specific ERα cistromes in endometrial tumors have largely been understudied. Moreover, the functional impact of non-coding somatic variants has commonly been underexplored and remained elusive. This study is aimed to provide functional interpretation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD029822 | Pride
Enhancers Endometrial cancer Er-alpha Somatic variants 
ProteomicsOn-chip AP-MS: Interaction proteomics on a microfluidics platform
Here we present a microfluidics-based affinity purification-mass spectrometry (AP-MS) pipeline to identify protein-protein interactions (PPI) using minute amounts of input material. The use of this automated platform allowed us to identify the human cohesin and CCC complex from only 4 micrograms of ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD011323 | Pride
Interaction proteomics Low input Ap-ms 
ProteomicsOn-chip AP-MS: Interaction proteomics on a microfluidics platform
Essentially all cellular processes are orchestrated by protein-protein interactions (PPIs). In recent years, affinity purification coupled to mass spectrometry (AP-MS) has been the preferred method to identify cellular PPIs. Here we present a microfluidics-based (AP-MS) workflow to identify PPIs usi...
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD012800 | Pride
Interaction proteomics Low input Ap-ms 
ProteomicsThe dynamic interactome of Polycomb family complexes during stem cell differentiation
While the core subunits of Polycomb group (PcG) complexes are well characterized, little is known about the dynamics of these protein complexes during cellular differentiation. We used quantitative interaction proteomics to study PcG proteins in mouse embryonic stem cells (mESCs) and neural progenit...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-19 | PXD003758 | Pride
Pr-dub Pcg Prc1 Prc2 
ProteomicsBreast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling output
Estrogen Receptor alpha (ERa) is the main driver of luminal breast cancer development and progression, and represents the main drug target in patient care. ERa chromatin binding has been extensively studied in breast cancer cell lines and a number of human tumors, often focused on differential bindi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD045526 | Pride
Breast cancer Estrogen receptor Enhancers Snps Rs9952980 
ProteomicsNuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells
The Nucleosome Remodeling and Deacetylase (NuRD) complex plays an important role in gene expression regulation, stem cell self-renewal, and lineage commitment. Yet little is known about the dynamics of NuRD during cellular differentiation. Here, we study these dynamics using genome-wide profiling an...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-11 | PXD010512 | Pride
Nurd Zfp296 Mouse Esc Npc 
GenomicsONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [scRNA-seq]
ONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [scRNA-seq]
PRJNA799363 | ENA
GenomicsONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [ATAC-seq]
ONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [ATAC-seq]
PRJNA799373 | ENA
GenomicsONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [ChIP-Seq]
ONECUT2 regulates RANKL-dependent Enterocyte and Microfold cell differentiation in the small intestine a multi-omics study [ChIP-Seq]
PRJNA799374 | ENA
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