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ProteomicsThe Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights
White adipose tissue plays a pivotal role in energy storage and release, and disruptions in these processes, marked by transcriptional disturbances, are linked to cardiometabolic diseases. Consequently, many efforts have focused on understanding adipose tissue function through transcriptional analys...
ORGANISM(S): Homo sapiens (Human) 
2025-03-17 | PXD057443 | Pride
Adipose tissue Human 
ProteomicsA Spatiotemporal Proteomic Map of Human Adipogenesis
White adipocytes function as the major energy reservoir in humans by storing large amounts of triglycerides. Their dysfunction is associated with metabolic disorders. However, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generated a spatiotemporal pr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD047412 | Pride
Bcaa Slc25a10 Adipocyte Wat Sgbs Adipogenesis Pcp Proteomic ruler Ocm Mpan Organelle proteomics C19orf12 Human 
ProteomicsTranscriptional determinants of lipid mobilization in human adipocytes
Defects in white adipose tissue lipolysis drive multiple aspects of cardiometabolic disease but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen in primary human adipocytes. Our analyses identified 37 transc...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD046964 | Pride
Coronary artery disease Lipolysis Type 2 diabetes Phosphodiesterase Znf189 Cad Pde1b2 T2dm Chip 
ProteomicsEPAC1 enhances energy expenditure by selectively inducing brown and beige adipose tissue growth
Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure (EE) and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show by phosphoproteomics that cAMP activates distinct sig...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-11 | PXD046709 | Pride
Brown adipocyte Epac 
ProteomicsFunctional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator
Insulin regulates adipocyte biology partly by modulating gene expression, still many insulin-responsive targets remain uncharacterized. Here, we integrate three transcriptomic datasets to define insulin-regulated genes and assess their functions in human adipocytes using a multiparametric lipid turn...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD072248 | Pride
Phosphoinositide lipase Lipolysis White adipose tissue Adipocyte Insulin action Lipogenesis Plcxd1 Lipid turnover 
ProteomicsC-COMPASS: A user-friendly neural network tool profiles cell compartments at protein and lipid levels
Systematic proteomic organelle profiling methods including Protein Correlation Profiling and LOPIT have advanced our understanding of cellular compartmentalization. To manage the complexity of organelle profiling data, we introduce C-COMPASS, a user-friendly open-source software that employs a neura...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-07-18 | PXD056457 | Pride
Organelle proteomics 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-12 | PXD048652 | Pride
Insulin inhibitory receptor Inceptor Diet-induced obesity Glucose homeostasis Insulin 
TranscriptomicsRhodospirillum rubrum S1H Space Flight Experiments
This SuperSeries is composed of the following subset Series: GSE14239: MESSAGE 2 space experiment with Rhodospirillum rubrum S1H GSE14241: BASE-A space experiment with Rhodospirillum rubrum S1H Refer to individual Series
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14265 | biostudies-arrayexpress
TranscriptomicsMESSAGE 2 space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid agar rich media was sent to the ISS in October 2003 (MESSAGE-part 2 experiment). After 10 days flight, R. rubrum cultures returned back to Earth. These cultures were then subjected to both transcriptomic and proteomic analysis and compared with the corresponding gr...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14239 | biostudies-arrayexpress
TranscriptomicsBASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight, R. rubrum cultures returned back to Earth. These cultures were then subjected to both transcriptomic and proteomic analysis and compared with the corresponding ground cont...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14241 | biostudies-arrayexpress
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