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ProteomicsGlobal quantitative proteomic analysis of aging Drosophila eyes
Wild-type Drosophila melanogaster expressing nuclear GFP-KASH fusion protein in photoreceptors for cell type-specific gene expression profiling (Rh1-Gal4>UAS-GFPKASH ; Genotype = w1118;; P{w+mC=[UAS-GFP-Msp300KASH}attP2, P{ry+t7.2=rh1-GAL4}3, ry506) were raised in 12:12h light:dark cycle at 25°C. Fl...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-07-23 | PXD027090 | Pride
Eye Drosophila Aging Lc-ms/ms 
ProteomicsBassoon contributes to tau-seed neurotoxicity and propagation.
Tau aggregates are critical pathological features of Alzheimer’s disease (AD) and other tauopathies. Growing evidence suggests that soluble tau aggregates trigger neurodegenerative phenotypes. However, the nature of the tau species and interactors involved in its aggregation and spreading remains un...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD027451 | Pride
Tauopathy Psp Bassoon. Brain Ad Tau Neurotoxicity Lc-msms Aggregation Propagation 
ProteomicsPLK1 inhibition induces synthetic lethality in Fanconi anemia pathway-deficient acute myeloid leukemia
Overall survival of acute myeloid leukemia (AML) remains limited. Inhibitors of the master mitotic kinase PLK1 have emerged as promising therapeutics, demonstrating efficacy in an undefined subset of AML patients. However, the clinical success of PLK1 inhibitors remains hindered by a lack of predict...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-09 | MSV000096625 | MassIVE
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