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ProteomicsThe prion protein interactome in four mouse cell lines of distinct lineages
At times, it can be difficult to discern if a lack of overlap in reported interactions for a protein-of-interest reflects differences in methodology or biology. A case in point is the prion protein (PrP) which is best known for its central role in prion disorders. Despite having over two dozen inter...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-24 | PXD008781 | Pride
Orbitrap fusion Mouse Interactome Prion 
ProteomicsSomatostatin-interacting human brain proteins
Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Recently, SST was observed to also interact with the amyloid beta (Aβ) pept...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD010885 | Pride
Somatostatin Brain Alzheimer disease Human Orbitrap Amyloid beta Neuroendocrine Biotinylation Endocrine Interactome 
ProteomicsMEF2A Interactome in rat cardiomyocyte
Myocyte enhancer factor 2 A was immunoprecipitated from primary cardiomyocytes then sequenced along with its binding partners by LC-MS2 with data dependent acquisition and simultaneous isobaric label based quantification.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-02-21 | PXD038574 | Pride
Heart Mef2a Rat Cardiomyocyte Interactome 
ProteomicsInteractomes of neural cell adhesion molecule 1 and the metal ion transporter ZIP6 in mouse NMuMG epithelial cells with transforming growth factor beta 1-induced fibroblastoid morphology
The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding PrP function. PrP and ZIP6 are required for the execution of a cellular program known as epi...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-13 | PXD004685 | Pride
Zip zinc transporter Prion protein Cell culture Crispr-cas9 knockout Orbitrap Mouse Immunoprecipitation Nmumg Epithelial-to-mesenchymal transition 
ProteomicsAstrocyte conditioned media-dependent Phosphatidylinositol 3-kinase interactome in mouse hippocampal neuron cell line Ht22
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. To identify proteins contributing to protective intracellular neuronal signalling originating from astrocytes, endogenous PI3K was immunoprecipi...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022200 | Pride
Neuron Brain Phosphatidylinositol 3-kinase Orbitrap Pi3k Neuroprotection Immunoprecipitation Astrocyte Itraq Interactome 
Proteomicsmouse brain prion protein interactome
In vertebrates, the prion protein (PrP, gene name Prnp) is expressed in diverse cell types and tissues, especially in the brain. In the adult brain, PrP contributes to homeostasis. Here, proteins expressed in the adult mouse brain which coimmunoprecipitated with PrP via the Fab antibody D18 were i...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD024870 | Pride
Neuron Orbitrap Immunoprecipitation Brain Interactome 
ProteomicsThe human amyloid beta peptide interactome
The amyloid beta (Aβ) peptide represents a 37 to 49 amino acids endoproteolytic fragment of the amyloid precursor protein. The cellular biology that governs the formation and clearance of Aβ has been understood to play a critical role in Alzheimer’s disease (AD). The primary objective of this study...
ORGANISM(S): Homo sapiens (Human) 
2017-07-05 | PXD004867 | Pride
Brain Affinity purification Alzheimer’s disease Human Frontal lobe Orbitrap Amyloid beta 
ProteomicsTime-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease
A hallmark of Alzheimer Disease is the accumulation of aggregation-prone amyloid beta peptides, which can assemble into smaller aggregates and deposit in the form of amyloid plaques. Here we used the recently introduced APPNL-F mouse model of Alzheimer Disease, which faithfully recapitulates the amy...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-02 | PXD004439 | Pride
Mouse Brain Amyloid beta Lc-ms/ms 
ProteomicsComparative interactome analyses of wild-type and P301L MAPT in two human neuronal cell lines
Protein interactions of the tau protein are of interest in efforts to decipher the mechanisms of cell death in Alzheimer Disease (AD), a subset of frontotemporal dementias (FTD) and other tauopathies. We recently reported on extensive interactions of tau with the ribonucleoproteome and chaperones. A...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD010040 | Pride
Tauopathy Neuron Alzheimer disease Human Frontotemporal dementia Inducible expression Orbitrap Tau Interactome Mapt 
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