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ProteomicsMYC sensitises cells to apoptosis by driving energetic demand
The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sens...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034517 | Pride
Nucleotide catabolism Pentose phosphate pathway Myc Energy Metabolic flux Nucleotide biosynthesis Apoptosis Glutamine Adenylate kinase 
ProteomicsHuman Beta Defensin-2-mediated protection of human skin barrier in vitro; a mechanistic evaluation
I this project we performed global proteomic and secretomic analyses, following HBD2 stimulation, with or without V8-mediated damage, demonstrating minimal impact of the peptide alone on undamaged cells and showing that HBD2 did not induce expression of known antiproteases, but rather may function b...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD037844 | Pride
Defensins  antimicrobial host defence peptide  atopic dermatitis  staphylococcus aureus 
ProteomicsA commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component
Condensin complexes compact and disentangle chromosomes in preparation for cell division. Commercially available antibodies raised against condensin subunits have been widely used to characterise their cellular interactome. Here we have assessed the specificity of a polyclonal antibody (Bethyl A302-...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-14 | PXD022664 | Pride
Swi/snf Condensin Antibody Ncaph2 Cross-react 
ProteomicsTMEM-98 bioID proximity labelling interactome
Investigation into the protein-protein interactome of TMEM-98 in humans
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD017091 | Pride
Bioid Tmem98 Human 
ProteomicsRegional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021270 | Pride
Maxquant Q exactive plus Immunoprecipitation On-beads digest 
ProteomicsA novel approach for the discovery of biomarkers of radiotherapy response in breast cancer
Radiotherapy is a commonly used treatment modality for the local control of breast cancer. However, the clinical signs of radiotherapy response are often not apparent for several weeks post-treatment. We currently lack tools to predict and/or monitor tumor responses during treatment. The aim of this...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD027572 | Pride
Radiosensitivity biomarkers Human breast cancer Secretome Radiotherapy Radioresistance 
ProteomicsA WDR35-dependent coatomer transports ciliary membrane proteins from the Golgi to the cilia
Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of cargo inside cilia. However, the mechanism of selective transport of cargo to cilia and entry across the diffusion barrier is not well understood. WDR35/IFT121 is a component of the IFT-A complex, best known...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-03 | PXD022652 | Pride
Wdr35 Ciliary membrane Cilia Ifta 
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
TranscriptomicsMicroarray data of foetal liver Lin- cKit+ cells obtained from Fh1-deficient and control 14.5 dpc mouse embryos
Haematopoiesis-specific Fh1 deletion causes lethal foetal liver haematopoietic defects. To understand the impact of Fh1 deletion on the transcriptome of foetal liver Lin- c-Kit+ cells we preformed microarray analysis. To conditionally delete Fh1 in the foetal liver we used the Vav-iCre recombinase a...
ORGANISM(S): Mus musculus 
2017-02-08 | E-MTAB-5425 | biostudies-arrayexpress
UnknownKDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability
Not available
S-JCBD-201607032 | bioimages
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