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ProteomicsCooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans
Comparative proteomic study between C. elegans wild type, mir-58.1 single, mir-80; mir-58.1 double and mir-80; mir-58.1; mir-81-82 quadruple mutants.
ORGANISM(S): Caenorhabditis elegans 
2015-08-06 | PXD001998 | Pride
Silac_celegan 
Proteomicsmouse liver SWATH-MS - Systems proteomics of liver mitochondria function
Here, we have profiled 386 individuals in 80 cohorts of the BXD mouse genetic reference population across two environmental states through a metabolic phenotyping program including glucose response, exercise capacity, and cold response. To understand how the observed phenotypic differences are relat...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-13 | PXD003266 | Pride
Mouse liver Swath-ms 
Proteomicsmouse stem cell SWATH-MS
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to SC senescence during aging. Here we demonstrate the importance of cellular NAD+ level and its impact on mitochondrial activity as a pivotal switch to modulate muscle stem cell (MuSC) senescence. Impor...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD003865 | Pride
Mouse stem cell Swath-ms 
ProteomicsMultilayered Omics Revealsl Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity
White adipose tissue (WAT) harbors functionally diverse subpopulations of adipose progenitor cells that differentially impact tissue plasticity in a sex- and depot-dependent manner. To date, the molecular basis of this cellular heterogeneity has not been fully defined. Here, we describe a multilayer...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD023829 | Pride
Multilayered omics Adipogenesis Inflammation Preadipocytes Ppar. Adipocyte precursor cells Cellular heterogeneity 
ProteomicsTargeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Illustrative of these are the many screens that have been conducted to find inhibitors for the Hedgehog (Hh) signaling pathway – a major developmental pathway with many implications in health and disease ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD040859 | Pride
Proteomics Protac 
ProteomicsTargeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Illustrative of these are the many screens that have been conducted to find inhibitors for the Hedgehog (Hh) signaling pathway – a major developmental pathway with many implications in health and disease ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036539 | Pride
Hedgehog pathway Protac Protein degradation 
ProteomicsMINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans
Post-transcriptional control of mRNAs by RNA-binding proteins (RBPs) has a prominent role in the regulation of gene expression. RBPs interact with mRNAs to control their biogenesis, splicing, transport, localization, translation, and stability. Defects in such regulation can lead to a wide range of ...
ORGANISM(S): Caenorhabditis elegans 
2021-09-08 | PXD011625 | Pride
Germ cell death Mina-1 C.elegans 
ProteomicsProteome validation for novel full-length genes in the giant panda
we applied RNA-seq to detect novel expressed transcripts in 12 tissues of giant pandas, using a transcriptome reconstruction strategy combining reference-based and de novo methods. Then we used mass spectrometry method to identify proteomes of five selected tissues, aiming at validating these novel...
ORGANISM(S): Ailuropoda melanoleuca (Giant panda) 
2015-12-23 | PXD002917 | Pride
Testis Pituitary Brain Giant panda Tongue Lc-ltq Ovary 
MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
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