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TranscriptomicsLow oxygen responsive small RNAs in Arabidopsis
Low-oxygen stress associated with natural phenomena such as waterlogging, results in widespread transcriptome changes and a metabolic switch from aerobic respiration to anaerobic fermentation. High-throughput sequencing of small RNA libraries obtained from low-oxygen stressed and control root tissue...
ORGANISM(S): Arabidopsis thaliana 
2009-09-30 | E-GEOD-16971 | biostudies-arrayexpress
TranscriptomicsCharacterization of the regulatory networks mediating TLR9 dependent gene activation in vivo
CpG DNA interacts with TLR9 to stimulate a broadly protective innate immune response. This study uses bioinformatic network analysis of microarray data to identify the genes and regulatory networks triggered by CpG ODN. CpG treatment induced significant gene up-regulation (p < 0.00001) in the spleen...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-11202 | biostudies-arrayexpress
ProteomicsSystematic analysis of intronic microRNAs reveals cooperativity within the multi-component FTX locus to promote colon cancer development
Approximately half of all microRNAs reside within intronic regions and are often co-transcribed with their host genes. However, most studies on intronic microRNAs focus on individual microRNAs, and conversely most studies on protein-coding and non-coding genes frequently ignore any intron-derived mi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD021823 | Pride
Micrornas A-to-i editing Colon cancer Long noncoding rna Post-transcriptional regulation 
ProteomicsZNF524 directly interacts with telomeric DNA and supports telomere integrity
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex blocks unwanted DNA damage repair at telomeres, e.g. by suppressing non-homologous end joining (NHEJ)...
ORGANISM(S): Homo sapiens (Human) 
2023-10-21 | PXD043084 | Pride
Trf2 Genome integrity Alt Telomeres Rap1 Znf524 Osteosarcoma 
ProteomicsA novel enzyme-mediated method for covalent surface modification of extracellular vesicles to achieve targeted drug delivery
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. However, existing methods to engineer target-specific EVs are tedious or inefficient, having to compromise betwee...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD021926 | Pride
Extracellular vesicles Rbcevs Drug delivery 
ProteomicsZNF524 directly binds telomeres and supports their integrity via TRF2/RAP1
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex consists of six proteins (TRF1, TRF2, RAP1, POT1, TPP1 and TIN2) and blocks unwanted DNA damage repai...
ORGANISM(S): Homo sapiens (Human) 
2023-10-21 | PXD024630 | Pride
Genome stability Telomeres Znf524 Bioid 
ProteomicsGlobal analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating mul...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD030215 | Pride
Post-transcriptional regulation Larp1 Myc Rna-binding protein Cancer 
ProteomicsPLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by the lack of patient selection marker. Using a high-...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD031110 | Pride
Oxidative phosphorylation Mitochondria Plk1 Arid1a Synthetic lethality 
UnknownHypoxia-responsive microRNAs and trans-acting small interfering RNAs in Arabidopsis.
Not available
S-EPMC2791121 | biostudies-literature
ProteomicsLens Disulfide crosslink
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-07-20 | MSV000079952 | MassIVE
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