Sort   by:  
 Page size 
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD026407 | Pride
Hnrnp r Yb1 Dna damage Motoneuron 
ProteomicshnRNP R Knock-out affects the axonal and somatic proteome
We grew neurons in microchambers to separate axons and soma in different compartments which could be independently harvested for proteomic analysis. Using this model system, we studied the effect of the knock-out of hnRNP R on the axonal and somatic proteome.
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD038368 | Pride
Hnrnp r Axon Proteome 
ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to Chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD022467 | Pride
Proteomics Hnrnpr Ip Ftld Als Motoneurons Dna damage response 
ProteomicshnRNPR interactome in axons and soma of murine motoneurons
We determined the protein interaction partners of hnRNP R in murine motoneuron axons and soma by immunoprecipitation-MS. The neurons were grown in microchambers and axons and soma could be harvested individually. We performed an IP with an antibody against the murine hnRNP R.
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD043851 | Pride
Hnrnpr Motoneuron Interactome Dda 
UnknownDNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis.
Not available
S-EPMC4267653 | biostudies-literature
ProteomicsAxonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer´s disease (AD). Tau pathology occurs first in axons of affected neurons and tau removal from axons might thus be an early intervention strategy. We report that the RNA-binding protein hnRN...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD053387 | Pride
Antisense oligonucleotide Alzheimer´s disease Amyloid Tau Hnrnp r 
UnknownhnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
Not available
S-EPMC11358521 | biostudies-literature
UnknownLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.
Not available
S-EPMC8643683 | biostudies-literature
UnknownCrystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Not available
S-EPMC4267654 | biostudies-literature
Sort   by:  
 Page size