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ProteomicsPeroxiredoxin 2 is required for the exercise induced redox mediated adaptation to exercise
During exercise there is a site-specific increase in ROS within muscle required for the beneficial adaptive response by activation of specific signalling pathways. Peroxiredoxin 2 (Prdx2), an abundant cytoplasmic 2-Cys peroxidase, is required for the adaptive beneficial hormesis response to H2O2, my...
ORGANISM(S): Caenorhabditis elegans 
2023-03-11 | PXD037698 | Pride
Caenorhabditis elegans redox 
ProteomicsEffect of an immune challenge and feed supplements on broiler chicken individual breast muscle protein synthesis
Optimization of broiler chicken breast muscle protein accretion is key for the efficient production of poultry meat, whose demand is steadily increasing. In a context where antimicrobial growth promoters use is being restricted, it is important to find alternatives as well as to characterize the eff...
ORGANISM(S): Gallus gallus (Chicken) 
2024-04-04 | PXD044325 | Pride
Chicken Citrus Fsr Muscle 
ProteomicsPhospho-proteomic characterization of CCDC6-RET
Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved mass spectrometry analysis together with a robust biochemical and biophysical characterization reveal the autophosphorylation kineti...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD053907 | Pride
Ccdc6 Phosphorylation Ret 
ProteomicsIntegrative multi-omic analysis of the SWI/SNF complex defines a new clinical subgroup of lung adenocarcinoma patients
Mammalian SWI/SNF complexes are ATP-dependent chromatin remodelers composed of varying combinations of subunits that, together, fine-tune transcriptional regulation and genome integrity. SWI/SNF complex subunits have been identified as major targets of mutations in several tumor types suggesting a r...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD017397 | Pride
Brg1 Ip Nl20 
ProteomicsHsa-miR-139-5p expression regulates the abundance of proteins related to poor survival cancer in CAL-62 thyroid cancer cell line
We studied the impact of hsa-miR-139-5p on the protein output by means of an iTRAQ-based approach. First, we established two CAL-62 isogenic cell lines expressing either the mature hsa-miR-139-5p or a non-targeting control upon a doxycycline inducible promoter (PTRE3G-tGFP, Dharmacon). Total protein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-13 | PXD011901 | Pride
Thyroid cancer Cal-62 Hsa-mir-139-5p Impact Itraq 
ProteomicsSenescent cells display an altered immunopeptidome and promote CD8-dependent antitumor immunity
Cellular senescence is a stress response known to activate innate immunity. However, how senescent cells interact with the adaptive immune system remains largely unexplored. Here, we show that senescent cells display an enhanced MHC class I antigen processing and presentation. Furthermore, senescent...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-10-18 | PXD033714 | Pride
Senescence Plasma membrane 
ProteomicsRank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but unlike that of luminal, the contribution of basal Rank signaling to mammary gland homeostasis remains poorly studied. Combining timely-regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD058134 | Pride
Rank signaling Phosphorylation Tumorogenesis 
ProteomicsTargeting mitochondrial translation overcomes multidrug resistance in FBXW7-deficient cells
FBXW7 is one of the most frequently mutated tumor suppressors, the deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatic analyses and genome-wide CRISPR screens, we here reveal that FBXW7 deficiency leads to multi-drug resistance (MDR), to a bigg...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-06-08 | PXD029981 | Pride
Tmt Q exactive Mescs 
ProteomicsMCRS1 is a histone acetylation regulator whose loss in hepatocytes promotes cirrhosis
Cirrhosis is a late stage of fibrosis that fatally impairs liver function. Unfortunately, genetic animal models mimicking human cirrhosis are lacking and the molecular mechanisms remain unknown. Here we report the first murine genetic model recapitulating clinical features of cirrhosis, which are in...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD023026 | Pride
Hepatocytes Mcrs1 Itraq 
ProteomicsUSP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at DNA replication forks
The AAA+ ATPase VCP regulates the extraction of SUMO and/or ubiquitin modified factors from chromatin. We previously showed that active DNA synthesis is associated with a SUMO-high and ubiquitin-low environment that is maintained by the deubiquitylase USP7. Here we unveil a functional cooperation be...
ORGANISM(S): Homo sapiens (Human) 
2021-09-12 | PXD018623 | Pride
Human Crosslinking Vcp Dsp Usp7 
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