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ProteomicsThe deubiquitinase USP13 maintains cancer cell stemness by promoting FASN stability in small cell lung cancer
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and...
ORGANISM(S): Homo Sapiens 
PXD032993 |
ProteomicsMultilayered Omics Revealsl Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity
White adipose tissue (WAT) harbors functionally diverse subpopulations of adipose progenitor cells that differentially impact tissue plasticity in a sex- and depot-dependent manner. To date, the molecular basis of this cellular heterogeneity has not been fully defined. Here, we describe a multilayer...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD023829 | Pride
Multilayered omics Adipogenesis Inflammation Preadipocytes Ppar. Adipocyte precursor cells Cellular heterogeneity 
UnknownSanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function.
Not available
S-EPMC12366350 | biostudies-literature
Proteomicsmouse stem cell SWATH-MS
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to SC senescence during aging. Here we demonstrate the importance of cellular NAD+ level and its impact on mitochondrial activity as a pivotal switch to modulate muscle stem cell (MuSC) senescence. Impor...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD003865 | Pride
Mouse stem cell Swath-ms 
ProteomicsProteome validation for novel full-length genes in the giant panda
we applied RNA-seq to detect novel expressed transcripts in 12 tissues of giant pandas, using a transcriptome reconstruction strategy combining reference-based and de novo methods. Then we used mass spectrometry method to identify proteomes of five selected tissues, aiming at validating these novel...
ORGANISM(S): Ailuropoda melanoleuca (Giant panda) 
2015-12-23 | PXD002917 | Pride
Testis Pituitary Brain Giant panda Tongue Lc-ltq Ovary 
MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
ProteomicsMass spectrometry data of PBMCs after PBS/SEMA3G treatment
The semaphorins encompass a substantial family of secreted and transmembrane glycoproteins, originally recognized as pivotal factors in guiding axonal growth during the development of neural circuitry. Recent studies have uncovered diverse functions of semaphorins in a wide array of immune responses...
ORGANISM(S): Homo Sapiens 
PXD057174 |
ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
ProteomicsStudy of biological function of VRK1 in the development and progress of prostate cancer
VRK1 plays a significant role in the growth and drug resistance of prostate cancer.
ORGANISM(S): Homo Sapiens 
2024-11-22 | PXD058205 |
ProteomicsProteomic analysis of ascites from LC and GC patients
Proteomic analysis by mass spectrometry was performed to characterize proteins in ascites samples from patients with gastric cancer (N = 7) or liver cirrhosis (N = 3).
ORGANISM(S): Homo Sapiens (human) 
2023-10-07 | PXD037200 | JPOST Repository
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