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UnknownGut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
Not available
S-EPMC9241845 | biostudies-literature
MetabolomicsThe Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism
The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active ...
2017-04-24 | MTBLS435 | MetaboLights
ProteomicsDICAR+/- mouse heart Label free LC-MS
The level of ubiquitin protein of the heart of DICAR+/- compared with wild type
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037732 | Pride
Heart Lc-msms 
ProteomicsProteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model
A total of 6527.0 proteins were identified in the First Affiliated Hospital of Sun Yat sen University, of which 5732.0 proteins contained quantitative information. If we take 1.5 times as the differential expression change threshold and t-test p-value < 0.05 as the significance threshold, we found t...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD046815 | Pride
Lupus nephritis artesunate tmt-based quantitative proteomics 
ProteomicsLicorice Ameliorates Cisplatin-Induced Hepatotoxicity through Anti-apoptosis, Anti-oxidative Stress, Anti-inflammation, and Acceleration of Metabolism
Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for poisons and drugs, and may be an effective dr...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD021688 | Pride
Proteomics Hepatotoxicity Detoxification Cisplatin Licorice 
ProteomicsUnveiling EMC6 as a Novel Pathogenic Determinant in hepatocellular carcinoma: Orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13
The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of ...
ORGANISM(S): Mus Musculus 
PXD067920 |
ProteomicsThe protein binding with diabetes induced circulation associated circular RNA of db/db mouse heart detected by label free LC-MSMS
The protein binding with diabetes induced circulation associated circular RNA (DICAR) pf db/db mouse compared with wild type
ORGANISM(S): Mus Musculus 
PXD037745 |
ProteomicsiTRAQ-based proteomic analysis of Deinococcus radiodurans in response to 12C6+ heavy ions irradiation
Proteome of Deinococcus radiodurans which were treaded by four different doses of heavy ion radiation.
ORGANISM(S): Deinococcus Radiodurans R1 
2022-02-28 | PXD031902 |
ProteomicsSIRT5 ameliorates cardiac fibrosis via PCK2 de-succinylation–mediated metabolic reprogramming in cardiac fibroblasts
WT and Sirt5-/- CFBs were stimulated with TGF-β1 (10 ng/mL) for 36 hours. Cells were harvested, snap-frozen, and stored at -80℃. The experiment was independently repeated six times at different time points. Cells from each replicate were pooled to yield more than 3 mg of protein per group. Pooled WT...
ORGANISM(S): Mus Musculus 
2025-11-15 | PXD070811 |
ProteomicsAn integrative multi-omics approach uncovers the regulatory role of Cdk7 and Cdk4 in autophagy induced by silica nanoparticles
The abnormal induction of macroautophagy/autophagy, a highly conserved lysosome-based degradation pathway, has been postulated as a major toxicity of nanomaterials, whereas little is known on the exact molecular mechanisms. Here, we treated mammalian cells with 16 nm silica nanoparticles (SiNPs), co...
ORGANISM(S): Rattus Norvegicus 
2019-12-01 | PXD012196 |
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